{"doi":"10.1093/cid/ciac098","title":"Geographical Differences in the Self-Reported Functional Impairment of People With Human Immunodeficiency Virus (HIV) and Associations With Cardiometabolic Risk","abstract":"BACKGROUND: We sought to explore multinational differences in functional status by global burden of disease (GBD) regions in the REPRIEVE cohort. METHODS: REPRIEVE is a prospective, double-blind, randomized, placebo-controlled, multicenter, phase III primary cardiovascular prevention study of pitavastatin calcium vs placebo among people with human immunodeficiency virus (HIV, PWH) ages 40-75 on antiretroviral therapy (ART). GBD super regions were defined using World Health Organization classifications. Participants were categorized by impairment on the Duke Activity Status Instrument (DASI: none, some, moderate, severe). Logistic regression models examined risk factors and GBD regions associated with functional impairment. The association between functional impairment and cardiometabolic risk was also explored. RESULTS: Of 7736 participants, the majority were from high-income countries (n = 4065), were male (65%), and had received ART for ≥ 10 years. The median DASI score was 58.2 (interquartile range [IQR] 50.2, 58.2); 36% reported at least some impairment. In adjusted analyses, functional impairment was significantly more frequent among participants from Southeast/East Asia. Other factors associated with greater impairment included female sex, Black race, older age, current/former smoking, higher body mass index, use of ART for ≥ 10 years, and select ART regimens; differences were seen in risks across GBD regions. Functional impairment was associated with increased cardiometabolic risk. CONCLUSIONS: Over 1/3 of middle-aged and older PWH in a global cohort across diverse GBD regions demonstrate functional impairments. The associations between DASI and cardiometabolic risk suggest that a measure of functional status may improve risk prediction; these longitudinal associations will be further investigated over REPRIEVE trial follow-up.","journal":"Clinical Infectious Diseases","year":2022,"id":280590,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9309,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":381594,"name":"Kathleen V. Fitch","orcid":"0000-0002-0541-3707","position":1,"is_corresponding":false},{"id":759908,"name":"Sara McCallum","orcid":"0000-0002-0289-1295","position":2,"is_corresponding":false},{"id":396977,"name":"Heather J. Ribaudo","orcid":"0000-0002-0394-3990","position":3,"is_corresponding":false},{"id":437399,"name":"Edgar T. Overton","orcid":"0000-0002-4013-536X","position":4,"is_corresponding":false},{"id":381595,"name":"Markella V. Zanni","orcid":"0000-0002-4711-3956","position":5,"is_corresponding":false},{"id":329844,"name":"Gerald S. Bloomfield","orcid":"0000-0002-7176-1611","position":6,"is_corresponding":false},{"id":109430,"name":"Todd T. Brown","orcid":"0000-0001-8599-278X","position":7,"is_corresponding":false},{"id":335272,"name":"Carl J. Fichtenbaum","orcid":"0000-0002-6778-7253","position":8,"is_corresponding":false},{"id":247281,"name":"Sara H Bares","orcid":"0000-0002-2130-2505","position":9,"is_corresponding":false},{"id":12096,"name":"Judith A. Aberg","orcid":"0000-0001-8162-0284","position":10,"is_corresponding":false},{"id":282488,"name":"Pamela S. Douglas","orcid":"0000-0001-9876-4049","position":11,"is_corresponding":false},{"id":445687,"name":"Evelynne S. Fulda","orcid":"0000-0001-5903-131X","position":12,"is_corresponding":false},{"id":434573,"name":"Jorge Santana‐Bagur","orcid":"0000-0003-2822-3401","position":13,"is_corresponding":false},{"id":955081,"name":"José G. Castro","orcid":"0000-0002-8642-1724","position":14,"is_corresponding":false},{"id":595786,"name":"Laura Moran","orcid":null,"position":15,"is_corresponding":false},{"id":326404,"name":"Vidya Mave","orcid":"0000-0001-8509-4517","position":16,"is_corresponding":false},{"id":354411,"name":"Khuanchai Supparatpinyo","orcid":"0000-0003-1838-4826","position":17,"is_corresponding":false},{"id":422249,"name":"Ponego Ponatshego","orcid":"0009-0006-7549-8300","position":18,"is_corresponding":false},{"id":955495,"name":"Mauro Schechter","orcid":null,"position":19,"is_corresponding":false},{"id":12007,"name":"Steven Grinspoon","orcid":"0000-0002-6338-000X","position":20,"is_corresponding":false},{"id":242505,"name":"Kristine M. Erlandson","orcid":"0000-0003-0808-6729","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T00:29:03.247347Z","pmid":"35165682","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}