{"doi":"10.1093/cid/ciab646","title":"Neutralizing Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants Induced by Natural Infection or Vaccination: A Systematic Review and Pooled Analysis","abstract":"Recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants may pose a threat to immunity. A systematic landscape of neutralizing antibodies against emerging variants is needed. We systematically searched for studies that evaluated neutralizing antibody titers induced by previous infection or vaccination against SARS-CoV-2 variants and collected individual data. We identified 106 studies meeting the eligibility criteria. Lineage B.1.351 (beta), P.1 (gamma) and B.1.617.2 (delta) significantly escaped natural infection-mediated neutralization, with an average of 4.1-fold (95% confidence interval [CI]: 3.6-4.7-fold), 1.8-fold (1.4-2.4-fold), and 3.2-fold (2.4-4.1-fold) reduction in live virus neutralization assay, while neutralizing titers against B.1.1.7 (alpha) decreased slightly (1.4-fold [95% CI: 1.2-1.6-fold]). Serum from vaccinees also led to significant reductions in neutralization of B.1.351 across different platforms, with an average of 7.1-fold (95% CI: 5.5-9.0-fold) for nonreplicating vector platform, 4.1-fold (3.7-4.4-fold) for messenger RNA platform, and 2.5-fold (1.7-2.9-fold) for protein subunit platform. Neutralizing antibody levels induced by messenger RNA vaccines against SARS-CoV-2 variants were similar to, or higher, than that derived from naturally infected individuals.","journal":"Clinical Infectious Diseases","year":2021,"id":148869,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":117,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":620567,"name":"Zhiyuan Chen","orcid":"0000-0003-1405-642X","position":1,"is_corresponding":false},{"id":78332,"name":"Andrew S. Azman","orcid":"0000-0001-8662-9077","position":2,"is_corresponding":false},{"id":620568,"name":"Ruijia Sun","orcid":"0000-0003-4366-6374","position":3,"is_corresponding":false},{"id":553033,"name":"Wanying Lu","orcid":null,"position":4,"is_corresponding":false},{"id":620569,"name":"Nan Zheng","orcid":"0000-0002-9117-6700","position":5,"is_corresponding":false},{"id":633094,"name":"Jiaxin Zhou","orcid":"0000-0002-6615-0752","position":6,"is_corresponding":false},{"id":286619,"name":"Qianhui Wu","orcid":"0000-0001-9146-0675","position":7,"is_corresponding":false},{"id":269880,"name":"Xiaowei Deng","orcid":"0000-0002-9892-2470","position":8,"is_corresponding":false},{"id":551788,"name":"Zeyao Zhao","orcid":"0000-0002-5230-735X","position":9,"is_corresponding":false},{"id":550607,"name":"Xinghui Chen","orcid":"0000-0002-6041-2993","position":10,"is_corresponding":false},{"id":633848,"name":"Shijia Ge","orcid":null,"position":11,"is_corresponding":false},{"id":269878,"name":"Juan Yang","orcid":"0000-0001-5028-2227","position":12,"is_corresponding":false},{"id":352714,"name":"Daniel T. Leung","orcid":"0000-0001-8401-0801","position":13,"is_corresponding":false},{"id":269885,"name":"Hongjie Yu","orcid":"0000-0002-6335-5648","position":14,"is_corresponding":false},{"id":406865,"name":"Xinhua Chen","orcid":"0000-0002-3944-3816","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T23:42:46.224799Z","pmid":"34302458","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}