{"doi":"10.1093/cid/ciab468","title":"Reply to Lapadula et al","abstract":"To the Editor—We reviewed with interest the comments of Lapadula and colleagues regarding our case-control study of bamlanivimab use in high-risk ambulatory patients with coronavirus disease 2019 (COVID-19) [1]. Their comments reinforce one of our major discussion points—the need for bamlanivimab to be administered as early as possible in the course of COVID-19. As noted, 12 (6.5%) control patients were ineligible to receive the antibody infusion due to severity of disease—either at time of presentation (4 patients) or at time of planned infusion (8 patients). Timelier initial presentation along with a streamlined referral and bamlanivimab administration process would have resulted in these patients receiving therapy. In consideration of the logistical challenges, we included these controls in our analysis. These patients represent the expected clinical trajectory of patients at high risk for decompensation to severe COVID-19 and reflect the de facto challenges clinicians face when caring for this...","journal":"Clinical Infectious Diseases","year":2021,"id":224259,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":660318,"name":"En‐Ling Wu","orcid":"0000-0002-5679-6277","position":1,"is_corresponding":false},{"id":377123,"name":"Valentina Stosor","orcid":"0000-0002-0388-5460","position":2,"is_corresponding":false},{"id":567175,"name":"William J Moore","orcid":"0000-0001-5385-354X","position":3,"is_corresponding":false},{"id":283131,"name":"Chad J. Achenbach","orcid":"0000-0003-4847-7249","position":4,"is_corresponding":false},{"id":283132,"name":"Michael G. Ison","orcid":"0000-0003-3347-9671","position":5,"is_corresponding":false},{"id":367297,"name":"Michael Angarone","orcid":"0000-0002-3728-7864","position":6,"is_corresponding":false},{"id":660317,"name":"Rebecca N. Kumar","orcid":"0000-0001-6650-0612","position":0,"is_corresponding":true}],"reference_count":9,"raw_metadata":null,"created_at":"2026-07-18T23:54:18.470602Z","pmid":"34015090","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}