{"doi":"10.1093/cid/ciab236","title":"Influence of Obesity on Clinical Manifestations and Response to Therapy in Cutaneous Leishmaniasis Caused by <i>Leishmania braziliensis</i>","abstract":"BACKGROUND: Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a single ulcer or multiple cutaneous lesions with raised borders. Cure rates <60% are observed in response to meglumine antimoniate therapy. We investigated the impact of obesity on CL clinical presentation and therapeutic response. METHODS: A total of 90 age-matched patients with CL were included (30 obese, 30 overweight, and 30 with normal body mass index [BMI]). CL was diagnosed through documentation of L. braziliensis DNA by polymerase chain reaction or identification of amastigotes in biopsied skin-lesion samples. Serum cytokine levels were determined by chemiluminescence. Antimony therapy with Glucantime (Sanofi-Aventis; 20 mg/kg/day) was administered for 20 days. RESULTS: Obese CL patients may present hypertrophic ulcers rather than typical oval, ulcerated lesions. A direct correlation between BMI and healing time was noted. After 1 course of antimony, cure was achieved in 73% of patients with normal BMI, 37% of overweight subjects, yet just 18% of obese CL patients (P < .01). Obese CL cases additionally presented higher leptin levels than overweight patients or those with normal BMI (P < .05). CONCLUSIONS: Obesity modifies the clinical presentation of CL and host immune response and is associated with greater failure to therapy.","journal":"Clinical Infectious Diseases","year":2021,"id":192771,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.827,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":416443,"name":"Lucas P. Carvalho","orcid":"0000-0001-5033-1666","position":1,"is_corresponding":false},{"id":680276,"name":"Maurício T. Nascimento","orcid":"0000-0002-3791-8048","position":2,"is_corresponding":false},{"id":416442,"name":"Luiz Henrique Guimarães","orcid":"0000-0002-0202-5661","position":3,"is_corresponding":false},{"id":446001,"name":"Jamile Lago","orcid":"0000-0002-5865-6163","position":4,"is_corresponding":false},{"id":497697,"name":"Léa Cristina Castellucci","orcid":"0000-0002-9625-2469","position":5,"is_corresponding":false},{"id":416441,"name":"Augusto M. Carvalho","orcid":"0000-0002-8031-4805","position":6,"is_corresponding":false},{"id":760497,"name":"Alex Lago","orcid":null,"position":7,"is_corresponding":false},{"id":416445,"name":"Edgar M. Carvalho","orcid":"0000-0002-2697-8002","position":8,"is_corresponding":false},{"id":498495,"name":"Tainã Lago","orcid":null,"position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T23:49:43.496702Z","pmid":"33725723","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}