{"doi":"10.1093/cid/ciaa982","title":"Strategies for Implementation Research to Investigate the Negative Pharmacokinetic Interaction Between Efavirenz and Dolutegravir","abstract":"(See the Brief Report Article by Haas and Acosta on pages 1820–2.) The report from Haas and Acosta in this issue of Clinical Infectious Diseases presents a pharmacokinetic and pharmacogenomic analysis utilizing plasma concentration and genotype data obtained during their study of healthy, white volunteers receiving efavirenz followed by dolutegravir. This study also examined the relationship of the CYP2B6 genotype polymorphism to the pharmacokinetic interaction between efavirenz and dolutegravir. The authors indicate that the safest strategy for using dolutegravir in a second-line regimen would be to switch directly from efavirenz-containing regimens only in individuals with an undetectable viral load. The implementation of this recommendation is likely to be variable among low- and middle-income countries (LMICs) and would likely be facilitated by additional clinical research. This complex interaction occurs when prior efavirenz dosing in certain individuals is discontinued but sustained efavirenz plasma concentrations result...","journal":"Clinical Infectious Diseases","year":2020,"id":130425,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":258962,"name":"Gene D. Morse","orcid":"0000-0001-6758-0941","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-18T23:15:53.196774Z","pmid":"32667998","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}