{"doi":"10.1093/cid/ciaa784","title":"Frequency and Determinant Factors for Calcification in Neurocysticercosis","abstract":"BACKGROUND: Neurocysticercosis is a major cause of acquired epilepsy. Larval cysts in the human brain eventually resolve and either disappear or leave a calcification that is associated with seizures. In this study, we assessed the proportion of calcification in parenchymal neurocysticercosis and risk factors associated with calcification. METHODS: Data for 220 patients with parenchymal NCC from 3 trials of antiparasitic treatment were assessed to determine what proportion of the cysts that resolved 6 months after treatment ended up in a residual calcification at 1 year. Also, we evaluated the risk factors associated with calcification. RESULTS: The overall proportion of calcification was 38% (188/497 cysts, from 147 patients). Predictors for calcification at the cyst level were cysts larger than 14 mm (risk ratio [RR], 1.34; 95% confidence interval [CI], 1.02-1.75) and cysts with edema at baseline (RR, 1.39; 95% CI, 1.05-1.85). At the patient level, having had more than 24 months with seizures (RR, 1.25; 95% CI, 1.08-1.46), mild antibody response (RR, 1.14; 95% CI, 1.002-1.27), increased dose albendazole regime (RR, 1.26; 95% CI, 1.14-1.39), lower doses of dexamethasone (RR, 1.36; 95% CI, 1.02-1.81), not receiving early antiparasitic retreatment (RR, 1.45; 95% CI, 1.08-1.93), or complete cure (RR, 1.48; 95% CI, 1.29-1.71) were associated with a increased risk of calcification. CONCLUSIONS: Approximately 38% of parenchymal cysts calcify after antiparasitic treatment. Some factors associated with calcification are modifiable and may be considered to decrease or avoid calcification, potentially decreasing the risk for seizure relapses.","journal":"Clinical Infectious Diseases","year":2020,"id":93771,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":467884,"name":"Gianfranco Arroyo","orcid":"0000-0001-8743-5012","position":1,"is_corresponding":false},{"id":304253,"name":"Robert H. Gilman","orcid":"0000-0002-9037-0712","position":2,"is_corresponding":false},{"id":467885,"name":"Percy Soto-Becerra","orcid":"0000-0001-5332-9254","position":3,"is_corresponding":false},{"id":467886,"name":"Isidro Gonzáles","orcid":"0000-0003-3897-0195","position":4,"is_corresponding":false},{"id":467887,"name":"Herbert Saavedra","orcid":"0009-0008-9249-068X","position":5,"is_corresponding":false},{"id":468696,"name":"E. Javier Pretell","orcid":null,"position":6,"is_corresponding":false},{"id":323516,"name":"Theodore E. Nash","orcid":"0000-0003-4619-0068","position":7,"is_corresponding":false},{"id":467888,"name":"Seth E. O’Neal","orcid":"0000-0002-4782-3368","position":8,"is_corresponding":false},{"id":467889,"name":"Óscar H. Del Brutto","orcid":"0000-0003-1917-8805","position":9,"is_corresponding":false},{"id":467890,"name":"Armando E. González","orcid":"0000-0003-1909-1873","position":10,"is_corresponding":false},{"id":455137,"name":"Héctor H. Garcı́a","orcid":"0000-0002-4633-6269","position":11,"is_corresponding":false},{"id":468697,"name":"The Cysticercosis Working Group in Peru","orcid":null,"position":12,"is_corresponding":false},{"id":467883,"name":"Javier A. Bustos","orcid":"0000-0002-5797-3052","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T22:31:34.149524Z","pmid":"32556276","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}