{"doi":"10.1093/cid/ciaa476","title":"Unexpected Results From a Phase 2 Trial of a Microbiome Therapeutic for <i>Clostridioides difficile</i> Infection: Lessons for the Future","abstract":"(See the Major Article by McGovern et al on pages 2132–40.) “Failure is only the opportunity more intelligently to begin again.” —Henry Ford Infection with toxigenic Clostridioides difficile in the setting of antibiotic administration has become the exemplar of a disease where the indigenous microbiota plays a central role in pathogenesis [1]. Alteration of the structure and function of the gut bacterial community renders the gastrointestinal tract conducive to germination of ingested spores and the vegetative outgrowth of the pathogen. While we are still unraveling the precise molecular mechanisms by which the indigenous microbiota normally maintains colonization resistance against C. difficile there has been a push to target the gut microbiota for therapy of C. difficile infection (CDI) and other enteric infections [2]. In particular, the restoration of the normal structure and function of the microbiota to prevent or break the cycle of C....","journal":"Clinical Infectious Diseases","year":2020,"id":111021,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237252,"name":"Vincent B. Young","orcid":"0000-0003-3687-2364","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-18T23:13:01.914939Z","pmid":"32330238","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}