{"doi":"10.1093/cid/ciaa327","title":"Risk Factors for Adverse Events in Household Contacts Prescribed Preventive Treatment for Drug-resistant Tuberculosis Exposure","abstract":"BACKGROUND: Completion of tuberculosis (TB) preventive treatment is important to optimize efficacy; treatment-related adverse events (AEs) sometimes result in discontinuation. This study describes the occurrence of AEs and their risk factors during a 6-month, 2-drug, fluoroquinolone-based preventive treatment for household contacts of patients with drug-resistant TB in Karachi, Pakistan. METHODS: The primary outcome was development of any clinical AE during preventive treatment. Adverse events were categorized using the AE grading tables of the National Institutes of Health. Time-to-event analysis with Kaplan-Meier curves and Cox proportional hazards models accounting for recurrence were used to analyze associated risk factors. RESULTS: Of the 172 household contacts on preventive treatment, 36 (21%) developed 64 AEs during 813 months of treatment. The incidence of AEs over 6 months of treatment was 7.9 per 100 person-months; 16 per 100 person-months with a fluoroquinolone and ethionamide, and 4.4 per 100 person-months with a fluoroquinolone and ethambutol. There were 53 (83%) grade 1 and 11 grade 2 AEs, with no grade 3 or 4 AEs. In multivariable analysis, the risk of AEs was higher in contacts prescribed ethionamide as compared to ethambutol adjusting for age, sex, and body mass index (adjusted hazard ratio, 2.1 [95% confidence interval {CI}, 1.2-3.6]). Overall, there was no notable difference in treatment completion among the contacts who experienced an AE and those who did not (crude odds ratio, 1.1 [95% CI, .52-2.5]). CONCLUSIONS: A fluoroquinolone-based preventive treatment regimen for drug-resistant TB exposure is well tolerated. Regimens with ethionamide are more likely to result in AEs.","journal":"Clinical Infectious Diseases","year":2020,"id":73954,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":234305,"name":"Mercedes C. Becerra","orcid":null,"position":1,"is_corresponding":false},{"id":387406,"name":"Timothy L. Lash","orcid":"0000-0002-5240-5195","position":2,"is_corresponding":false},{"id":387407,"name":"Lisa M. Cranmer","orcid":"0000-0002-6938-9195","position":3,"is_corresponding":false},{"id":23206,"name":"Saad B. Omer","orcid":"0000-0002-5383-3474","position":4,"is_corresponding":false},{"id":389204,"name":"Junaid Fuad","orcid":null,"position":5,"is_corresponding":false},{"id":387408,"name":"Sara Siddiqui","orcid":"0000-0003-3942-1593","position":6,"is_corresponding":false},{"id":387410,"name":"Farhana Amanullah","orcid":"0000-0003-1168-4463","position":7,"is_corresponding":false},{"id":387412,"name":"Maria Jaswal","orcid":"0000-0002-2362-7661","position":8,"is_corresponding":false},{"id":387416,"name":"Naseem Salahuddin","orcid":"0000-0003-0566-5872","position":9,"is_corresponding":false},{"id":387417,"name":"Salmaan Keshavjee","orcid":"0000-0002-6967-3305","position":10,"is_corresponding":false},{"id":387418,"name":"Hamidah Hussain","orcid":"0000-0002-6585-9815","position":11,"is_corresponding":false},{"id":308895,"name":"Neel R. Gandhi","orcid":"0000-0002-1665-299X","position":12,"is_corresponding":false},{"id":105798,"name":"Amyn A. Malik","orcid":"0000-0003-4875-9916","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T21:45:52.171053Z","pmid":"32266942","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}