{"doi":"10.1093/cid/ciaa1693","title":"Severe Acute Respiratory Syndrome Coronavirus 2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study","abstract":"BACKGROUND: Child with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection typically have mild symptoms that do not require medical attention, leaving a gap in our understanding of the spectrum of SARS-CoV-2-related illnesses that the viruses causes in children. METHODS: We conducted a prospective cohort study of children and adolescents (aged <21 years) with a SARS-CoV-2-infected close contact. We collected nasopharyngeal or nasal swabs at enrollment and tested for SARS-CoV-2 using a real-time polymerase chain reaction assay. RESULTS: Of 382 children, 293 (77%) were SARS-CoV-2-infected. SARS-CoV-2-infected children were more likely to be Hispanic (P < .0001), less likely to have asthma (P = .005), and more likely to have an infected sibling contact (P = .001) than uninfected children. Children aged 6-13 years were frequently asymptomatic (39%) and had respiratory symptoms less often than younger children (29% vs 48%; P = .01) or adolescents (29% vs 60%; P < .001). Compared with children aged 6-13 years, adolescents more frequently reported influenza-like (61% vs 39%; P < .001) , and gastrointestinal (27% vs 9%; P = .002), and sensory symptoms (42% vs 9%; P < .0001) and had more prolonged illnesses (median [interquartile range] duration: 7 [4-12] vs 4 [3-8] days; P = 0.01). Despite the age-related variability in symptoms, wWe found no difference in nasopharyngeal viral load by age or between symptomatic and asymptomatic children. CONCLUSIONS: Hispanic ethnicity and an infected sibling close contact are associated with increased SARS-CoV-2 infection risk among children, while asthma is associated with decreased risk. Age-related differences in clinical manifestations of SARS-CoV-2 infection must be considered when evaluating children for coronavirus disease 2019 and in developing screening strategies for schools and childcare settings.","journal":"Clinical Infectious Diseases","year":2020,"id":61634,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5664,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":322353,"name":"Sarah M. Heston","orcid":"0000-0001-6150-1149","position":1,"is_corresponding":false},{"id":327475,"name":"Hailey N. Chambers","orcid":null,"position":2,"is_corresponding":false},{"id":325724,"name":"Hannah Cunningham","orcid":"0009-0005-1263-3344","position":3,"is_corresponding":false},{"id":325725,"name":"Meghan Price","orcid":"0000-0002-2683-9758","position":4,"is_corresponding":false},{"id":325726,"name":"Lilianna Suarez","orcid":"0000-0003-3066-2550","position":5,"is_corresponding":false},{"id":327476,"name":"Carter Crew","orcid":null,"position":6,"is_corresponding":false},{"id":288417,"name":"Shree Bose","orcid":"0000-0003-3350-0733","position":7,"is_corresponding":false},{"id":327477,"name":"Jhoanna N. Aquino","orcid":null,"position":8,"is_corresponding":false},{"id":327478,"name":"Stuart Carr","orcid":null,"position":9,"is_corresponding":false},{"id":325727,"name":"Shannon M. Griffin","orcid":"0000-0001-6043-7448","position":10,"is_corresponding":false},{"id":325728,"name":"Stephanie H. Smith","orcid":"0009-0006-0971-428X","position":11,"is_corresponding":false},{"id":322354,"name":"Kirsten Jenkins","orcid":"0000-0003-3814-0546","position":12,"is_corresponding":false},{"id":327479,"name":"Trevor S. Pfeiffer","orcid":null,"position":13,"is_corresponding":false},{"id":322434,"name":"Javier Rodriguez","orcid":"0000-0001-9608-5069","position":14,"is_corresponding":false},{"id":327480,"name":"C. Todd DeMarco","orcid":null,"position":15,"is_corresponding":false},{"id":327481,"name":"Nicole A. De Naeyer","orcid":null,"position":16,"is_corresponding":false},{"id":327482,"name":"Thaddeus C. Gurley","orcid":null,"position":17,"is_corresponding":false},{"id":327483,"name":"Raul Louzao","orcid":null,"position":18,"is_corresponding":false},{"id":325729,"name":"Congwen Zhao","orcid":"0000-0002-8540-6880","position":19,"is_corresponding":false},{"id":325730,"name":"Coleen K. Cunningham","orcid":"0000-0002-7725-3052","position":20,"is_corresponding":false},{"id":325731,"name":"William J. Steinbach","orcid":"0000-0002-5446-1094","position":21,"is_corresponding":false},{"id":325732,"name":"Thomas N. Denny","orcid":"0000-0002-7364-8276","position":22,"is_corresponding":false},{"id":327484,"name":"Debra J. Lugo","orcid":null,"position":23,"is_corresponding":false},{"id":32982,"name":"M. Anthony Moody","orcid":null,"position":24,"is_corresponding":false},{"id":240902,"name":"Sallie R. Permar","orcid":"0000-0003-1438-4554","position":25,"is_corresponding":false},{"id":325733,"name":"Alexandre T. Rotta","orcid":"0000-0002-4406-2276","position":26,"is_corresponding":false},{"id":3909,"name":"Nicholas A. Turner","orcid":"0000-0003-0650-4894","position":27,"is_corresponding":false},{"id":325734,"name":"Emmanuel B. Walter","orcid":"0000-0001-6502-6736","position":28,"is_corresponding":false},{"id":33039,"name":"Christopher W. Woods","orcid":"0000-0001-7240-2453","position":29,"is_corresponding":false},{"id":322359,"name":"Matthew S. Kelly","orcid":"0000-0001-8819-2315","position":30,"is_corresponding":false},{"id":325723,"name":"Jillian H. Hurst","orcid":"0000-0001-5079-9920","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T21:09:47.114172Z","pmid":"33141180","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}