{"doi":"10.1093/cid/ciaa1548","title":"Convalescent Plasma for Patients With Severe Coronavirus Disease 2019 (COVID-19): A Matched Cohort Study","abstract":"BACKGROUND: The efficacy of convalescent plasma (CP) for the treatment of coronavirus disease 2019 (COVID-19) remains unclear. METHODS: In a matched cohort analysis of hospitalized patients with severe COVID-19, the impact of CP treatment on in-hospital mortality was evaluated using univariate and multivariate Cox proportional-hazards models, and the impact of CP treatment on time to hospital discharge was assessed using a stratified log-rank analysis. RESULTS: In total, 64 patients who received CP a median of 7 days after symptom onset were compared to a matched control group of 177 patients. The incidence of in-hospital mortality was 12.5% and 15.8% in the CP and control groups, respectively (P = .52). There was no significant difference in the risk of in-hospital mortality between the 2 groups (adjusted hazard ratio [aHR] 0.93, 95% confidence interval [CI] .39-2.20). The overall rate of hospital discharge was not significantly different between the 2 groups (rate ratio [RR] 1.28, 95% CI .91-1.81), although there was a significantly increased rate of hospital discharge among patients 65-years-old or greater who received CP (RR 1.86, 95% CI 1.03-3.36). There was a greater than expected frequency of transfusion reactions in the CP group (2.8% reaction rate observed per unit transfused). CONCLUSIONS: We did not demonstrate a significant difference in risk of mortality or rate of hospital discharge between the CP and control groups. There was a signal for improved outcomes among the elderly, and further adequately powered randomized studies should target this subgroup when assessing the efficacy of CP treatment.","journal":"Clinical Infectious Diseases","year":2020,"id":61613,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.94,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":325651,"name":"Fadi Shehadeh","orcid":"0000-0002-9552-4004","position":1,"is_corresponding":false},{"id":325652,"name":"Evangelia K. Mylona","orcid":"0000-0002-5365-5348","position":2,"is_corresponding":false},{"id":268927,"name":"Josiah D. Rich","orcid":"0000-0002-4517-7841","position":3,"is_corresponding":false},{"id":327447,"name":"Marguerite A. Neill","orcid":null,"position":4,"is_corresponding":false},{"id":325653,"name":"Francine Touzard-Romo","orcid":"0000-0002-5101-5443","position":5,"is_corresponding":false},{"id":327448,"name":"Sara Geffert","orcid":null,"position":6,"is_corresponding":false},{"id":327449,"name":"Jerome Larkin","orcid":null,"position":7,"is_corresponding":false},{"id":242456,"name":"Jeffrey A. Bailey","orcid":"0000-0002-6899-8204","position":8,"is_corresponding":false},{"id":325654,"name":"Shaolei Lu","orcid":"0000-0003-2870-5793","position":9,"is_corresponding":false},{"id":325655,"name":"Joseph Sweeney","orcid":"0000-0003-2734-4877","position":10,"is_corresponding":false},{"id":285512,"name":"Eleftherios Mylonakis","orcid":"0000-0002-4624-0777","position":11,"is_corresponding":false},{"id":325650,"name":"Ralph Rogers","orcid":"0000-0003-0268-0188","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T21:09:47.114172Z","pmid":"33038227","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}