{"doi":"10.1093/cid/ciaa1539","title":"Toll-like Receptor 7 Agonists in People Living With HIV: Implications for Immunotherapeutic Strategies for an HIV Cure","abstract":"(See the Major Article by Riddler et al on pages e815–24.) Combination antiretroviral therapy (ART) can potently suppress HIV to very low or undetectable levels but treatment is required life long. This is because HIV can integrate in the DNA of long-lived and proliferating CD4+ T cells and, rather than complete the virus life cycle, persists in a silent form with minimal or no viral transcription. As a result, these cells are not cleared by HIV-specific T-cells and are not responsive to antiretroviral drugs [1]. To achieve a cure or control of virus replication off ART, there is significant interest in interventions capable of both reducing the pool of infected cells and enhancing immune control. Activating HIV transcription and protein expression in latently infected cells to allow for immune recognition is one approach to reduce the pool of infected cells. This is often referred to as...","journal":"Clinical Infectious Diseases","year":2020,"id":109350,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":299394,"name":"Sharon R. Lewin","orcid":"0000-0002-0330-8241","position":1,"is_corresponding":false},{"id":522125,"name":"Thomas A. Rasmussen","orcid":"0000-0001-5354-2442","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T23:12:50.712357Z","pmid":"33044543","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}