{"doi":"10.1093/cid/ciaa1360","title":"Heaping the Pelion of Vancomycin on the Ossa of Methicillin-resistant Staphylococcus <i>aureus</i>: Back to Basics in Clinical Care and Guidelines","abstract":"(See the Viewpoints Article by Dilworth et al on pages e675–81.) In Greek mythology, the Titans piled Mount Pelion and Mount Ossa upon Olympus to scale the dwellings of the Gods but were overwhelmed by Zeus. “Heaping Pelion upon Ossa” thus refers to making monumental efforts that nevertheless fail to achieve their objective. This aphorism applies well to the never-ending struggle of having medical guidelines accelerate the translation of research into clinical practice, improve the quality and safety of healthcare, and reduce inappropriate practice variation [1]. The Viewpoint article by Dilworth et al that appears in this issue of Clinical Infectious Diseaseshelps underscore this dilemma [2]. Some years ago, national practice guidelines were published recommending that vancomycin dosing be adjusted to maintain trough (Cmin) serum concentrations between 15 and 20 µg/mL [3]. The evidence supporting this recommendation was based on hypothesis-generating,...","journal":"Clinical Infectious Diseases","year":2020,"id":81387,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420770,"name":"Sarah C J Jorgensen","orcid":"0000-0003-1333-0378","position":1,"is_corresponding":false},{"id":420771,"name":"Brad Spellberg","orcid":"0000-0002-3632-1709","position":2,"is_corresponding":false},{"id":420769,"name":"William F. Wright","orcid":"0000-0003-4235-6518","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-18T21:52:34.401799Z","pmid":"32901250","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}