{"doi":"10.1093/cid/ciaa1303","title":"Fatty Liver Disease in a Prospective North American Cohort of Adults With Human Immunodeficiency Virus and Hepatitis B Virus Coinfection","abstract":"BACKGROUND: Hepatitis B virus (HBV) and fatty liver disease (FLD) are common in human immunodeficiency virus (HIV). Correlates of FLD and its relationship with alanine aminotransferase (ALT) were examined longitudinally in HIV-HBV coinfection. METHODS: From 28/4/2014-7/11/2018, 114 HIV-HBV adults had liver biopsy and were followed for a median of 3 years (ancillary study of Hepatitis B Research Network). Steatohepatitis was based on presence of steatosis, ballooning, and perisinusoidal fibrosis. FLD was defined as ≥5% steatosis and/or steatohepatitis. RESULTS: Median age was 49 years, 93% were male, 51% black, 93% had HIV RNA <400 copies/mL and 83% HBV DNA <1000 IU/mL. Thirty percent had FLD (20% steatosis, 10% steatohepatitis). Those with FLD had higher median triglyceride (171 vs 100 mg/dL, P < .01) and small, dense LDL (44 vs 29 mg/dL, P < .01) and lower HDL-2-C (9 vs 12 mg/dL, P = .001). After adjusting for age, sex, and alcohol use, white and other versus black race (ORs, 8.49 and 16.54, respectively), ALT (OR, 3.13/doubling), hypertension (OR, 10.93), hyperlipidemia (OR, 4.36), and diabetes family history (OR, 5.38) were associated with having FLD (all P < .05). Steatohepatitis or steatosis alone (vs none) was associated with higher ALT over time (1.93 and 1.34 times higher, respectively; P < .001), with adjustment for age, sex, and HBV DNA. CONCLUSIONS: About 30% with HIV-HBV coinfection had FLD including 10% with steatohepatitis. FLD was associated with non-black race, metabolic risks, an atherogenic lipid profile, and elevated ALT over time. Thus, identification of FLD and management of adverse metabolic profiles are critically important in HIV-HBV coinfection. Clinical Trial Registration. NCT01924455.","journal":"Clinical Infectious Diseases","year":2020,"id":77518,"datarank":0.814568693034198,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.36520885200109926,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.36520885200109926,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":16,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7429,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01924455"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":381749,"name":"Wendy C. King","orcid":"0000-0002-0740-0029","position":1,"is_corresponding":false},{"id":225662,"name":"David E. Kleiner","orcid":"0000-0003-3442-4453","position":2,"is_corresponding":false},{"id":104967,"name":"Mamta K. Jain","orcid":"0000-0003-2292-6544","position":3,"is_corresponding":false},{"id":270866,"name":"Raymond T. Chung","orcid":"0000-0001-7587-718X","position":4,"is_corresponding":false},{"id":315359,"name":"Mark Sulkowski","orcid":"0000-0002-2145-6352","position":5,"is_corresponding":false},{"id":404033,"name":"Mauricio Lisker‐Melman","orcid":"0000-0001-7929-6841","position":6,"is_corresponding":false},{"id":404034,"name":"David Wong","orcid":"0000-0002-3310-3538","position":7,"is_corresponding":false},{"id":270560,"name":"Marc G. Ghany","orcid":"0000-0003-2837-0188","position":8,"is_corresponding":false},{"id":260246,"name":"Arun J. Sanyal","orcid":"0000-0001-8682-5748","position":9,"is_corresponding":false},{"id":325248,"name":"Richard K. Sterling","orcid":"0000-0002-8637-2475","position":10,"is_corresponding":false},{"id":336587,"name":"Mandana Khalili","orcid":"0000-0001-9178-9139","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:49:16.197289Z","pmid":"32869840","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}