{"doi":"10.1093/cid/ciaa088","title":"Clinical Features of Human Metapneumovirus-Associated Community-acquired Pneumonia Hospitalizations","abstract":"BACKGROUND: Human metapneumovirus (HMPV) is a leading cause of respiratory tract infections. Few studies have compared the clinical characteristics and severity of HMPV-associated pneumonia with other pathogens. METHODS: Active, population-based surveillance was previously conducted for radiographically confirmed, community-acquired pneumonia hospitalizations among children and adults in 8 United States hospitals. Clinical data and specimens for pathogen detection were systematically collected. We described clinical features of all HMPV-associated pneumonia and, after excluding codetections with other pathogen types, we compared features of HMPV-associated pneumonia with other viral, atypical, and bacterial pneumonia and modeled the severity (mild, moderate, and severe) and length of stay using multivariable proportional odds regression. RESULTS: HMPV was detected in 298/2358 (12.6%) children and 88/2320 (3.8%) adults hospitalized with pneumonia and was commonly codetected with other pathogens (125/298 [42%] children and 21/88 [24%] adults). Fever and cough were the most common presenting symptoms of HMPV-associated pneumonia and were also common symptoms of other pathogens. After excluding codetections in children (n = 1778), compared to HMPV (reference), bacterial pneumonia exhibited increased severity (odds ratio [OR], 3.66; 95% confidence interval [CI], 1.43-9.40), respiratory syncytial virus (RSV; OR, 0.76; 95% CI, .59-.99) and atypical (OR, 0.39; 95% CI, .19-.81) infections exhibited decreased severity, and other viral pneumonia exhibited similar severity (OR, 0.88; 95% CI, .55-1.39). In adults (n = 2145), bacterial (OR, 3.74; 95% CI, 1.87-7.47) and RSV pneumonia (OR, 1.82; 95% CI, 1.32-2.50) were more severe than HMPV (reference), but all other pathogens had similar severity. CONCLUSIONS: Clinical features did not reliably distinguish HMPV-associated pneumonia from other pathogens. HMPV-associated pneumonia was less severe than bacterial and adult RSV pneumonia, but was otherwise as or more severe than other common pathogens.","journal":"Clinical Infectious Diseases","year":2020,"id":62043,"datarank":0.5983476069846413,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":0.0,"self_endowment_contribution":0.5983476069846413,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8666,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":294609,"name":"Kathryn M. Edwards","orcid":"0000-0003-3912-9832","position":1,"is_corresponding":false},{"id":105909,"name":"Yuwei Zhu","orcid":"0000-0001-9849-1634","position":2,"is_corresponding":false},{"id":105907,"name":"Carlos G. Grijalva","orcid":"0000-0002-2329-7797","position":3,"is_corresponding":false},{"id":106002,"name":"Wesley H. Self","orcid":"0000-0002-9300-3045","position":4,"is_corresponding":false},{"id":328311,"name":"Seema Jain","orcid":"0000-0002-6342-8288","position":5,"is_corresponding":false},{"id":330090,"name":"Krow Ampofo","orcid":null,"position":6,"is_corresponding":false},{"id":328312,"name":"Andrew T. Pavia","orcid":"0000-0002-3066-580X","position":7,"is_corresponding":false},{"id":328313,"name":"Sandra R. Arnold","orcid":"0000-0001-6130-8154","position":8,"is_corresponding":false},{"id":330091,"name":"Jonathan A. McCullers","orcid":null,"position":9,"is_corresponding":false},{"id":94484,"name":"Evan J. Anderson","orcid":"0000-0002-1576-4420","position":10,"is_corresponding":false},{"id":266702,"name":"Richard G. Wunderink","orcid":"0000-0002-8527-4195","position":11,"is_corresponding":false},{"id":328314,"name":"Derek J. Williams","orcid":"0000-0003-0295-1240","position":12,"is_corresponding":false},{"id":328310,"name":"Leigh M. Howard","orcid":"0000-0003-4301-7235","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:10:11.612909Z","pmid":"32010955","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}