{"doi":"10.1093/cid/ciaa041","title":"Clinical Metagenomics for Bloodstream Infections: Is the Juice Worth the Squeeze?","abstract":"(See the Major Article by Hogan et al on pages 239–45.) Bloodstream infections (BSIs) are a significant cause of morbidity and mortality, accounting for $20 billion in hospitalization costs and high in-hospital mortality [1]. In the current surviving sepsis guidelines, blood culture is the only microbiology test recommended to support the diagnosis of sepsis [2]. However, blood culture has limited sensitivity (ranging from 5% to 50%) and is affected by several preanalytical variables including timing of collection (eg, before or after initiation of antimicrobial therapy) and volume of blood collected [3, 4]. In 2014, Charles Chiu and colleagues from the University of California, San Francisco (UCSF) reported the first use of unbiased, next-generation sequencing (NGS) on cerebrospinal fluid (CSF) to diagnose a case of neuroleptospirosis in a 14-year-old boy presenting with meningoencephalitis [5]. Fewer than 500 reads (out of...","journal":"Clinical Infectious Diseases","year":2020,"id":99687,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9588,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":228382,"name":"N. Esther Babady","orcid":"0000-0003-4399-1249","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-18T22:38:09.754371Z","pmid":"31942942","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}