{"doi":"10.1093/cercor/bhw360","title":"The Basal Radial Glia Occurs in Marsupials and Underlies the Evolution of an Expanded Neocortex in Therian Mammals","abstract":null,"journal":"Cerebral Cortex","year":2018,"id":647667,"datarank":0.7885879398157775,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.28349356531780623,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.28349356531780623,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":22,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1687543,"name":"Brandon R Menzies","orcid":null,"position":1,"is_corresponding":false},{"id":1687545,"name":"Megan Glatzle","orcid":null,"position":2,"is_corresponding":false},{"id":1592525,"name":"Johannes Seeger","orcid":null,"position":3,"is_corresponding":false},{"id":1687548,"name":"Marilyn B Renfree","orcid":null,"position":4,"is_corresponding":false},{"id":1687550,"name":"Simone A Fietz","orcid":null,"position":5,"is_corresponding":false},{"id":1687541,"name":"Christine Sauerland","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Basal Radial Glia Occurs in Marsupials and Underlies the Evolution of an Expanded Neocortex in Therian Mammals","abstract":"A hallmark of mammalian brain evolution is the emergence of the neocortex, which has expanded in all mammalian infraclasses (Eutheria, Marsupialia, Monotremata). In eutherians, neocortical neurons derive from distinct neural stem and progenitor cells (NPCs). However, precise data on the presence and abundance of the NPCs, especially of basal radial glia (bRG), in the neocortex of marsupials are lacking. This study characterized and quantified the NPCs in the developing neocortex of a marsupial, the tammar wallaby (Macropus eugenii). Our data demonstrate that its neocortex is characterized by high NPC diversity. Importantly, we show that bRG exist at high relative abundance in the tammar indicating that this cell type is not specific to the eutherian neocortex and that similar mechanisms may underlie the formation of an expanded neocortex in eutherian and marsupial mammals. We also show that bRG are likely to have been present in the therian ancestor, so did not emerge independently in the eutherian and marsupial lineages. Moreover, our data support the concept that changes in multiple parameters contribute to neocortex expansion and demonstrate the importance of bRG and other NPCs for the development and expansion of the mammalian neocortex.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29253253","pmcid":null,"openalex_id":"https://openalex.org/W2551021411","authors":[],"funders":[{"funder_name":"Deutscher Akademischer Austauschdienst/German Academic Exchange Service","grant_id":"57141544","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft/German Research Foundation","grant_id":"1565/3-1","title":null},{"funder_name":"Australian GO8","grant_id":"","title":null}],"total_grants":3,"fwci":1.9656,"citation_percentile":0.86554239,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":8},{"year":2020,"count":3},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":6},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/cercor/article-pdf/28/1/145/22709993/bhw360.pdf","host_type":"journal"},{"url":"https://academic.oup.com/cercor/article-pdf/28/1/145/22709993/bhw360.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/cercor/article-pdf/28/1/145/22709993/bhw360.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/cercor/bhw360","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29253253","host_type":"repository"}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Cancer-related molecular mechanisms research","Neuroinflammation and Neurodegeneration Mechanisms","Animals","Biological Evolution","Cell Division","Cerebral Ventricles","Ependymoglial Cells","Immunohistochemistry","Macropodidae","Neocortex","Neural Stem Cells","Neurogenesis","PAX6 Transcription Factor","Phylogeny","Sheep, Domestic","Species Specificity","T-Box Domain Proteins"],"mesh_terms":["PAX6 Transcription Factor","Animals","Cell Division","Cerebral Ventricles","Biological Evolution","Immunohistochemistry","Macropodidae","Phylogeny","Species Specificity","Neocortex","T-Box Domain Proteins","Sheep, Domestic","Neurogenesis","Neural Stem Cells","Ependymoglial Cells"],"keywords":["Neocortex","Marsupial","Tammar wallaby","Biology","Brushtail possum","Theria","Macropus","Evolutionary biology","Neuroscience","Paleontology","Cenozoic","Evolution","Neurogenesis","Neocortex Development","Basal Radial Glia"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T01:42:59.692062Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}