{"doi":"10.1093/cercor/bhae243","title":"Globus pallidus externus drives increase in network-wide alpha power with propofol-induced loss-of-consciousness in humans","abstract":"States of consciousness are likely mediated by multiple parallel yet interacting cortico-subcortical recurrent networks. Although the mesocircuit model has implicated the pallidocortical circuit as one such network, this circuit has not been extensively evaluated to identify network-level electrophysiological changes related to loss of consciousness (LOC). We characterize changes in the mesocircuit in awake versus propofol-induced LOC in humans by directly simultaneously recording from sensorimotor cortices (S1/M1) and globus pallidus interna and externa (GPi/GPe) in 12 patients with Parkinson disease undergoing deep brain stimulator implantation. Propofol-induced LOC is associated with increases in local power up to 20 Hz in GPi, 35 Hz in GPe, and 100 Hz in S1/M1. LOC is likewise marked by increased pallidocortical alpha synchrony across all nodes, with increased alpha/low beta Granger causal (GC) flow from GPe to all other nodes. In contrast, LOC is associated with decreased network-wide beta coupling and beta GC from M1 to the rest of the network. Results implicate an important and possibly central role of GPe in mediating LOC-related increases in alpha power, supporting a significant role of the GPe in modulating cortico-subcortical circuits for consciousness. Simultaneous LOC-related suppression of beta synchrony highlights that distinct oscillatory frequencies act independently, conveying unique network activity.","journal":"Cerebral Cortex","year":2024,"id":468219,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.945,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420424,"name":"Mahsa Malekmohammadi","orcid":"0000-0002-2395-7134","position":1,"is_corresponding":false},{"id":623419,"name":"Daniel Toker","orcid":"0000-0003-0983-8937","position":2,"is_corresponding":false},{"id":420425,"name":"Hiro Sparks","orcid":"0000-0003-2915-7514","position":3,"is_corresponding":false},{"id":1259970,"name":"Amirreza Alijanpourotaghsara","orcid":"0000-0001-6942-9997","position":4,"is_corresponding":false},{"id":420423,"name":"Jeong Woo Choi","orcid":"0000-0001-5824-8859","position":5,"is_corresponding":false},{"id":1051749,"name":"Andrew E. Hudson","orcid":"0000-0001-7292-5406","position":6,"is_corresponding":false},{"id":337518,"name":"Martin M. Monti","orcid":"0000-0001-5511-3780","position":7,"is_corresponding":false},{"id":237692,"name":"Nader Pouratian","orcid":"0000-0002-0426-3241","position":8,"is_corresponding":false},{"id":1105080,"name":"Jasmine A. Thum","orcid":"0000-0003-4137-2137","position":0,"is_corresponding":true}],"reference_count":101,"raw_metadata":null,"created_at":"2026-07-19T02:05:19.071498Z","pmid":"38850214","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}