{"doi":"10.1093/cercor/bhae041","title":"Intrauterine exposure to SARS-CoV-2 infection and early newborn brain development","abstract":"Epidemiologic studies suggest that prenatal exposures to certain viruses may influence early neurodevelopment, predisposing offspring to neuropsychiatric conditions later in life. The long-term effects of maternal COVID-19 infection in pregnancy on early brain development, however, remain largely unknown. We prospectively enrolled infants in an observational cohort study for a single-site study in the Washington, DC Metropolitan Area from June 2020 to November 2021 and compared these infants to pre-pandemic controls (studied March 2014-February 2020). The primary outcomes are measures of cortical morphometry (tissue-specific volumes), along with global and regional measures of local gyrification index, and sulcal depth. We studied 210 infants (55 infants of COVID-19 unexposed mothers, 47 infants of COVID-19-positive mothers, and 108 pre-pandemic healthy controls). We found increased cortical gray matter volume (182.45 ± 4.81 vs. 167.29 ± 2.92) and accelerated sulcal depth of the frontal lobe (5.01 ± 0.19 vs. 4.40 ± 0.13) in infants of COVID-19-positive mothers compared to controls. We found additional differences in infants of COVID-19 unexposed mothers, suggesting both maternal viral exposures, as well as non-viral stressors associated with the pandemic, may influence early development and warrant ongoing follow-up.","journal":"Cerebral Cortex","year":2024,"id":439781,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":243153,"name":"Yuan-Chiao Lu","orcid":"0000-0002-9822-1375","position":1,"is_corresponding":false},{"id":243152,"name":"Yao Wu","orcid":"0000-0003-0443-8571","position":2,"is_corresponding":false},{"id":243156,"name":"Kushal Kapse","orcid":"0000-0001-8363-5404","position":3,"is_corresponding":false},{"id":1251076,"name":"Jennifer M. Keller","orcid":"0000-0001-5774-3225","position":4,"is_corresponding":false},{"id":1251490,"name":"Isabelle Von Kohorn","orcid":null,"position":5,"is_corresponding":false},{"id":1251491,"name":"A A Afifi","orcid":null,"position":6,"is_corresponding":false},{"id":243159,"name":"Gilbert Vézina","orcid":"0000-0002-1999-336X","position":7,"is_corresponding":false},{"id":1251492,"name":"Deidtra Henderson","orcid":null,"position":8,"is_corresponding":false},{"id":542160,"name":"David Wessel","orcid":null,"position":9,"is_corresponding":false},{"id":503116,"name":"Adré du Plessis","orcid":"0000-0003-3144-8791","position":10,"is_corresponding":false},{"id":243160,"name":"Catherine Limperopoulos","orcid":"0000-0003-1735-0069","position":11,"is_corresponding":false},{"id":243158,"name":"Nickie Andescavage","orcid":"0000-0002-6812-7898","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T02:00:52.633010Z","pmid":"38385890","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}