{"doi":"10.1093/cercor/bhac191","title":"Habenular connectivity predict weight loss and negative emotional-related eating behavior after laparoscopic sleeve gastrectomy","abstract":"Habenular (Hb) processes negative emotions that may drive compulsive food-intake. Its functional changes were reported following laparoscopic-sleeve-gastrectomy (LSG). However, structural connectivity (SC) of Hb-homeostatic/hedonic circuits after LSG remains unclear. We selected regions implicated in homeostatic/hedonic regulation that have anatomical connections with Hb as regions-of-interest (ROIs), and used diffusion-tensor-imaging with probabilistic tractography to calculate SC between Hb and these ROIs in 30 obese participants before LSG (PreLSG) and at 12-month post-LSG (PostLSG12) and 30 normal-weight controls. Three-factor-eating-questionnaire (TFEQ) and Dutch-eating-behavior-questionnaire (DEBQ) were used to assess eating behaviors. LSG significantly decreased weight, negative emotion, and improved self-reported eating behavior. LSG increased SC between the Hb and homeostatic/hedonic regions including hypothalamus (Hy), bilateral superior frontal gyri (SFG), left amygdala (AMY), and orbitofrontal cortex (OFC). TFEQ-hunger negatively correlated with SC of Hb-Hy at PostLSG12; and increased SC of Hb-Hy correlated with reduced depression and DEBQ-external eating. TFEQ-disinhibition negatively correlated with SC of Hb-bilateral SFG at PreLSG. Increased SC of Hb-left AMY correlated with reduced DEBQ-emotional eating. Higher percentage of total weight-loss negatively correlated with SC of Hb-left OFC at PreLSG. Enhanced SC of Hb-homeostatic/hedonic regulatory regions post-LSG may contribute to its beneficial effects in improving eating behaviors including negative emotional eating, and long-term weight-loss.","journal":"Cerebral Cortex","year":2022,"id":270819,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":301100,"name":"Gang Ji","orcid":"0000-0001-7500-7192","position":1,"is_corresponding":false},{"id":301101,"name":"Guanya Li","orcid":"0000-0002-3886-3966","position":2,"is_corresponding":false},{"id":935110,"name":"Yang Hu","orcid":"0000-0002-7316-508X","position":3,"is_corresponding":false},{"id":301102,"name":"Wenchao Zhang","orcid":"0000-0002-6227-3464","position":4,"is_corresponding":false},{"id":886323,"name":"Weibin Ji","orcid":null,"position":5,"is_corresponding":false},{"id":935605,"name":"Zongxin Tan","orcid":null,"position":6,"is_corresponding":false},{"id":631828,"name":"Hao Li","orcid":"0000-0002-6294-6761","position":7,"is_corresponding":false},{"id":886322,"name":"Fukun Jiang","orcid":null,"position":8,"is_corresponding":false},{"id":885609,"name":"Yaqi Zhang","orcid":"0000-0003-0901-2609","position":9,"is_corresponding":false},{"id":429966,"name":"Yaqi Zhang","orcid":"0000-0002-8281-3122","position":10,"is_corresponding":false},{"id":885610,"name":"Feifei Wu","orcid":"0000-0001-6875-6267","position":11,"is_corresponding":false},{"id":301105,"name":"Karen M. von Deneen","orcid":"0000-0002-5310-1003","position":12,"is_corresponding":false},{"id":935111,"name":"Juan Yu","orcid":"0000-0001-8281-5729","position":13,"is_corresponding":false},{"id":301106,"name":"Yu Han","orcid":"0000-0002-4125-6470","position":14,"is_corresponding":false},{"id":301107,"name":"Guangbin Cui","orcid":"0000-0002-7935-9803","position":15,"is_corresponding":false},{"id":301110,"name":"Peter Manza","orcid":"0000-0002-0791-357X","position":16,"is_corresponding":false},{"id":301111,"name":"Dardo Tomasi","orcid":"0000-0003-0183-5678","position":17,"is_corresponding":false},{"id":109148,"name":"Nora D. 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