{"doi":"10.1093/cercor/bhab387","title":"Individualized Functional Subnetworks Connect Human Striatum and Frontal Cortex","abstract":"The striatum and cerebral cortex are interconnected via multiple recurrent loops that play a major role in many neuropsychiatric conditions. Primate corticostriatal connections can be precisely mapped using invasive tract-tracing. However, noninvasive human research has not mapped these connections with anatomical precision, limited in part by the practice of averaging neuroimaging data across individuals. Here we utilized highly sampled resting-state functional connectivity MRI for individual-specific precision functional mapping (PFM) of corticostriatal connections. We identified ten individual-specific subnetworks linking cortex-predominately frontal cortex-to striatum, most of which converged with nonhuman primate tract-tracing work. These included separable connections between nucleus accumbens core/shell and orbitofrontal/medial frontal gyrus; between anterior striatum and dorsomedial prefrontal cortex; between dorsal caudate and lateral prefrontal cortex; and between middle/posterior putamen and supplementary motor/primary motor cortex. Two subnetworks that did not converge with nonhuman primates were connected to cortical regions associated with human language function. Thus, precision subnetworks identify detailed, individual-specific, neurobiologically plausible corticostriatal connectivity that includes human-specific language networks.","journal":"Cerebral Cortex","year":2021,"id":154537,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8603,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244869,"name":"Timothy O. Laumann","orcid":"0000-0002-0428-427X","position":1,"is_corresponding":false},{"id":244880,"name":"Scott Marek","orcid":"0000-0003-0032-9052","position":2,"is_corresponding":false},{"id":244868,"name":"Dillan J. Newbold","orcid":"0000-0002-5826-3546","position":3,"is_corresponding":false},{"id":244871,"name":"Jacqueline M. Hampton","orcid":"0000-0003-0175-5360","position":4,"is_corresponding":false},{"id":550012,"name":"Nicole A. Seider","orcid":"0000-0003-1511-1515","position":5,"is_corresponding":false},{"id":244872,"name":"David F. Montez","orcid":"0000-0003-1672-8218","position":6,"is_corresponding":false},{"id":656006,"name":"Ashley M Nielsen","orcid":null,"position":7,"is_corresponding":false},{"id":244879,"name":"Andrew N. Van","orcid":"0000-0002-8787-0943","position":8,"is_corresponding":false},{"id":259382,"name":"Annie Zheng","orcid":"0000-0002-8047-9458","position":9,"is_corresponding":false},{"id":498953,"name":"Ryland L. Miller","orcid":"0000-0002-9607-9491","position":10,"is_corresponding":false},{"id":655012,"name":"Joshua S. Siegel","orcid":"0000-0002-5752-3641","position":11,"is_corresponding":false},{"id":550009,"name":"Benjamin P. Kay","orcid":"0000-0003-3628-8029","position":12,"is_corresponding":false},{"id":15947,"name":"Abraham Z. Snyder","orcid":"0000-0002-3379-9627","position":13,"is_corresponding":false},{"id":244881,"name":"Deanna J. Greene","orcid":"0000-0002-0739-7771","position":14,"is_corresponding":false},{"id":32641,"name":"Bradley L. Schlaggar","orcid":"0000-0002-9246-2469","position":15,"is_corresponding":false},{"id":32642,"name":"Steven E. Petersen","orcid":"0000-0002-8911-3639","position":16,"is_corresponding":false},{"id":656007,"name":"Steven M Nelson","orcid":null,"position":17,"is_corresponding":false},{"id":244883,"name":"Nico U.F. Dosenbach","orcid":"0000-0002-6876-7078","position":18,"is_corresponding":false},{"id":244882,"name":"Evan M. Gordon","orcid":"0000-0002-2276-5237","position":0,"is_corresponding":true}],"reference_count":127,"raw_metadata":null,"created_at":"2026-07-18T23:43:54.469024Z","pmid":"34718460","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}