{"doi":"10.1093/cercor/bhab130","title":"Resting-State Network Alterations Differ between Alzheimer’s Disease Atrophy Subtypes","abstract":"Several Alzheimer's disease (AD) atrophy subtypes were identified, but their brain network properties are unclear. We analyzed data from two independent datasets, including 166 participants (103 AD/63 controls) from the DZNE-longitudinal cognitive impairment and dementia study and 151 participants (121 AD/30 controls) from the AD neuroimaging initiative cohorts, aiming to identify differences between AD atrophy subtypes in resting-state functional magnetic resonance imaging intra-network connectivity (INC) and global and nodal network properties. Using a data-driven clustering approach, we identified four AD atrophy subtypes with differences in functional connectivity, accompanied by clinical and biomarker alterations, including a medio-temporal-predominant (S-MT), a limbic-predominant (S-L), a diffuse (S-D), and a mild-atrophy (S-MA) subtype. S-MT and S-D showed INC reduction in the default mode, dorsal attention, visual and limbic network, and a pronounced reduction of \"global efficiency\" and decrease of the \"clustering coefficient\" in parietal and temporal lobes. Despite severe atrophy in limbic areas, the S-L exhibited only marginal global network but substantial nodal network failure. S-MA, in contrast, showed limited impairment in clinical and cognitive scores but pronounced global network failure. Our results contribute toward a better understanding of heterogeneity in AD with the detection of distinct differences in functional connectivity networks accompanied by CSF biomarker and cognitive differences in AD subtypes.","journal":"Cerebral Cortex","year":2021,"id":186495,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8083,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":744627,"name":"Ersin Ersoezlue","orcid":"0000-0001-6503-5894","position":1,"is_corresponding":false},{"id":264180,"name":"Sophia Stoecklein","orcid":"0000-0003-0325-4674","position":2,"is_corresponding":false},{"id":98783,"name":"Daniel Keeser","orcid":"0000-0002-0244-1024","position":3,"is_corresponding":false},{"id":647716,"name":"Frederic Brosseron","orcid":"0000-0003-3137-7516","position":4,"is_corresponding":false},{"id":84352,"name":"Katharina Büerger","orcid":null,"position":5,"is_corresponding":false},{"id":744628,"name":"Peter Dechent","orcid":"0009-0006-4005-3352","position":6,"is_corresponding":false},{"id":745355,"name":"Laura Dobisch","orcid":null,"position":7,"is_corresponding":false},{"id":77895,"name":"Birgit Ertl‐Wagner","orcid":"0000-0001-5306-7549","position":8,"is_corresponding":false},{"id":647718,"name":"Klaus Fließbach","orcid":"0000-0002-0183-7510","position":9,"is_corresponding":false},{"id":744629,"name":"John­–Dylan Haynes","orcid":"0000-0003-1786-6954","position":10,"is_corresponding":false},{"id":225475,"name":"Michael T. Heneka","orcid":"0000-0003-4996-1630","position":11,"is_corresponding":false},{"id":744630,"name":"Enise I. Incesoy","orcid":"0000-0003-2014-4098","position":12,"is_corresponding":false},{"id":647719,"name":"Daniel Janowitz","orcid":"0009-0003-4090-547X","position":13,"is_corresponding":false},{"id":647720,"name":"Ingo Kilimann","orcid":"0000-0002-3269-4452","position":14,"is_corresponding":false},{"id":399047,"name":"Christoph Laske","orcid":null,"position":15,"is_corresponding":false},{"id":648799,"name":"Coraline D. Metzger","orcid":null,"position":16,"is_corresponding":false},{"id":647721,"name":"Matthias H. Munk","orcid":"0000-0002-5339-4045","position":17,"is_corresponding":false},{"id":613829,"name":"Oliver Peters","orcid":"0000-0003-0568-2998","position":18,"is_corresponding":false},{"id":554056,"name":"Josef Priller","orcid":"0000-0001-7596-0979","position":19,"is_corresponding":false},{"id":613835,"name":"Alfredo Ramı́rez","orcid":"0000-0003-4991-763X","position":20,"is_corresponding":false},{"id":744631,"name":"Sandra Roeske","orcid":"0000-0002-8262-4356","position":21,"is_corresponding":false},{"id":648800,"name":"Nina Roy","orcid":null,"position":22,"is_corresponding":false},{"id":384838,"name":"Klaus Scheffler","orcid":"0000-0001-6316-8773","position":23,"is_corresponding":false},{"id":65622,"name":"Anja Schneider","orcid":"0000-0001-9540-8700","position":24,"is_corresponding":false},{"id":588066,"name":"Annika Spottke","orcid":"0000-0001-9854-2972","position":25,"is_corresponding":false},{"id":745356,"name":"Eike Jakob Spruth","orcid":null,"position":26,"is_corresponding":false},{"id":312311,"name":"Stefan Teipel","orcid":"0000-0002-3586-3194","position":27,"is_corresponding":false},{"id":648802,"name":"Maike Tscheuschler","orcid":null,"position":28,"is_corresponding":false},{"id":745357,"name":"Ruth Vukovich","orcid":null,"position":29,"is_corresponding":false},{"id":6042,"name":"Michael Wagner","orcid":"0000-0003-2589-6440","position":30,"is_corresponding":false},{"id":473736,"name":"Jens Wiltfang","orcid":"0000-0003-1492-5330","position":31,"is_corresponding":false},{"id":744632,"name":"Renat Yakupov","orcid":"0000-0002-3868-284X","position":32,"is_corresponding":false},{"id":745358,"name":"Emrah Duezel","orcid":null,"position":33,"is_corresponding":false},{"id":251468,"name":"Frank Jessen","orcid":"0000-0003-1067-2102","position":34,"is_corresponding":false},{"id":7728,"name":"Robert Perneczky","orcid":"0000-0003-1981-7435","position":35,"is_corresponding":false},{"id":745359,"name":"for the DELCODE study group and the Alzheimer's Disease Neuroimaging Initiative (ADNI)","orcid":null,"position":36,"is_corresponding":false},{"id":84349,"name":"Boris‐Stephan Rauchmann","orcid":"0000-0003-4547-6240","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T23:48:46.850806Z","pmid":"34080613","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}