{"doi":"10.1093/cercor/bhaa332","title":"Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline—Results From the Lifebrain Consortium","abstract":"We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18-92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. \"PSQI # 1 Subjective sleep quality\" and \"PSQI #5 Sleep disturbances\" were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with \"PSQI #5 Sleep disturbances\" emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.","journal":"Cerebral Cortex","year":2020,"id":63512,"datarank":1.2374668908352704,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.6664675173697223,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.6664675173697223,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":31,"citers_with_citation_signal":27,"citers_with_endowment":27,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8748,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01634841"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255766,"name":"Øystein Sørensen","orcid":"0000-0003-0724-3542","position":1,"is_corresponding":false},{"id":107775,"name":"Inge K. Amlien","orcid":"0000-0002-8508-9088","position":2,"is_corresponding":false},{"id":267972,"name":"David Bartrés‐Faz","orcid":"0000-0001-6020-4118","position":3,"is_corresponding":false},{"id":336228,"name":"Andreas M. Brandmaier","orcid":"0000-0001-8765-6982","position":4,"is_corresponding":false},{"id":336229,"name":"Nikolaus Buchmann","orcid":"0000-0002-4345-3515","position":5,"is_corresponding":false},{"id":336230,"name":"Ilja Demuth","orcid":"0000-0002-4340-2523","position":6,"is_corresponding":false},{"id":277047,"name":"Christian A. Drevon","orcid":"0000-0002-7216-2784","position":7,"is_corresponding":false},{"id":313175,"name":"Sandra Düzel","orcid":null,"position":8,"is_corresponding":false},{"id":315533,"name":"Klaus P. Ebmeier","orcid":"0000-0002-5190-7038","position":9,"is_corresponding":false},{"id":336231,"name":"Paolo Ghisletta","orcid":"0000-0001-7731-2406","position":10,"is_corresponding":false},{"id":338108,"name":"Ane‐Victoria Idland","orcid":null,"position":11,"is_corresponding":false},{"id":336232,"name":"Tim C. Kietzmann","orcid":"0000-0001-8076-6062","position":12,"is_corresponding":false},{"id":257919,"name":"Rogier Kievit","orcid":"0000-0003-0700-4568","position":13,"is_corresponding":false},{"id":312036,"name":"Simone Kühn","orcid":"0000-0001-6823-7969","position":14,"is_corresponding":false},{"id":312035,"name":"Ulman Lindenberger","orcid":"0000-0001-8428-6453","position":15,"is_corresponding":false},{"id":336233,"name":"Fredrik Magnussen","orcid":"0000-0003-2574-1705","position":16,"is_corresponding":false},{"id":336234,"name":"Dídac Macià","orcid":"0000-0003-3315-7293","position":17,"is_corresponding":false},{"id":255763,"name":"Athanasia M. 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