{"doi":"10.1093/cercor/bhaa266","title":"Genome-Wide Association Analysis of Neonatal White Matter Microstructure","abstract":"A better understanding of genetic influences on early white matter development could significantly advance our understanding of neurological and psychiatric conditions characterized by altered integrity of axonal pathways. We conducted a genome-wide association study (GWAS) of diffusion tensor imaging (DTI) phenotypes in 471 neonates. We used a hierarchical functional principal regression model (HFPRM) to perform joint analysis of 44 fiber bundles. HFPRM revealed a latent measure of white matter microstructure that explained approximately 50% of variation in our tractography-based measures and accounted for a large proportion of heritable variation in each individual bundle. An intronic SNP in PSMF1 on chromosome 20 exceeded the conventional GWAS threshold of 5 x 10-8 (p = 4.61 x 10-8). Additional loci nearing genome-wide significance were located near genes with known roles in axon growth and guidance, fasciculation, and myelination.","journal":"Cerebral Cortex","year":2020,"id":106697,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.829,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311892,"name":"Kai Xia","orcid":"0000-0003-1326-0891","position":1,"is_corresponding":false},{"id":514511,"name":"Mihye Ahn","orcid":"0000-0002-0388-7036","position":2,"is_corresponding":false},{"id":494122,"name":"Shaili C. Jha","orcid":"0000-0002-1208-6839","position":3,"is_corresponding":false},{"id":514512,"name":"Reid Blanchett","orcid":"0000-0003-4082-7603","position":4,"is_corresponding":false},{"id":62338,"name":"James J. Crowley","orcid":"0000-0001-9051-1557","position":5,"is_corresponding":false},{"id":28799,"name":"Jin Szatkiewicz","orcid":"0000-0002-4898-7401","position":6,"is_corresponding":false},{"id":323089,"name":"Fei Zou","orcid":"0000-0002-6637-3593","position":7,"is_corresponding":false},{"id":14290,"name":"Hongtu Zhu","orcid":"0000-0002-6781-2690","position":8,"is_corresponding":false},{"id":266786,"name":"Martin Styner","orcid":"0000-0002-8747-5118","position":9,"is_corresponding":false},{"id":314179,"name":"John H. Gilmore","orcid":"0000-0002-0939-6764","position":10,"is_corresponding":false},{"id":311897,"name":"Rebecca Knickmeyer","orcid":"0000-0001-7708-1388","position":11,"is_corresponding":false},{"id":136611,"name":"J Zhang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":138,"raw_metadata":null,"created_at":"2026-07-18T23:12:31.053776Z","pmid":"33009551","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}