{"doi":"10.1093/cei/uxae063","title":"Tim-4 alleviates acute hepatic injury by modulating homeostasis and function of NKT cells","abstract":"T-cell immunoglobulin and mucin domain-containing molecule 4 (Tim-4) is an immune checkpoint molecule, which involves in numerous inflammatory diseases. Tim-4 is mainly expressed on antigen-presenting cells. However, increasing evidence has shown that Tim-4 is also expressed on natural killer T (NKT) cells. The role of Tim-4 in maintaining NKT cell homeostasis and function remains unknown. In this study, we explored the effect of Tim-4 on NKT cells in acute liver injury. This study found that Tim-4 expression on hepatic NKT cells was elevated during acute liver injury. Tim-4 deficiency enhanced IFN-γ, TNF-α expression while impaired IL-4 production in NKT cells. Loss of Tim-4 drove NKT-cell effector lineages to be skewed to NKT1 subset. Furthermore, Tim-4 KO mice were more susceptible to α-Galactosylceramide (α-GalCer) challenge. In conclusion, our findings indicate that Tim-4 plays an important role in regulating homeostasis and function of NKT cells in acute liver injury. Therefore, Tim-4 might become a new regulator of NKT cells and a potential target for the therapy of acute hepatitis.","journal":"Clinical & Experimental Immunology","year":2024,"id":462149,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":457323,"name":"Yuzhen Wang","orcid":"0000-0002-7544-7937","position":1,"is_corresponding":false},{"id":1291597,"name":"Yutong Ge","orcid":"0000-0001-9994-8229","position":2,"is_corresponding":false},{"id":1292014,"name":"Zhuanchang Wu","orcid":null,"position":3,"is_corresponding":false},{"id":284821,"name":"Xuetian Yue","orcid":"0000-0001-5561-4964","position":4,"is_corresponding":false},{"id":1122675,"name":"Chunyang Li","orcid":"0000-0002-5798-2274","position":5,"is_corresponding":false},{"id":1292015,"name":"Xiaohong Liang","orcid":null,"position":6,"is_corresponding":false},{"id":1291598,"name":"Chunhong Ma","orcid":"0000-0002-8121-4718","position":7,"is_corresponding":false},{"id":238206,"name":"Pei Wang","orcid":"0000-0002-1650-3353","position":8,"is_corresponding":false},{"id":1291599,"name":"Lifen Gao","orcid":"0000-0003-2404-7439","position":9,"is_corresponding":false},{"id":471253,"name":"Yingchun Wang","orcid":"0000-0002-3405-706X","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:04:20.631898Z","pmid":"39036980","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}