{"doi":"10.1093/carcin/bgaf007","title":"Yes-associated protein plays oncogenic roles in human sporadic colorectal adenomas","abstract":"The role of Hippo-Yes-associated protein (YAP) in human colorectal cancer (CRC) presents contradictory results. We examined the function of YAP in the early stages of CRC by quantitatively measuring the expression of phospho-YAPS127 (p-YAP) and five APC-related proteins in 145 sporadic adenomas from the Tennessee Colorectal Polyp Study, conducting APC sequencing for 114 adenomas, and analyzing YAP-correlated cancer pathways using gene expression data from 326 adenomas obtained from Gene Expression Omnibus. The p-YAP expression was significantly correlated with YAP expression (r = 0.53, P < .0001) and nuclear β-catenin (r = 0.26, P = .0018) in adenoma tissues. Both p-YAP and nuclear β-catenin were associated with APC mutations (P = .05). A strong association was observed between p-YAP overexpression and advanced adenoma odds (OR = 12.62, 95% CI = 4.57-34.86, P trend < .001), which persisted after adjusting for covariates and biomarkers (OR = 12.31, 95% CI = 3.78-40.10, P trend < .0001). P-YAP exhibited a sensitivity of 77.4% and specificity of 78.2% in defining advanced versus nonadvanced adenomas. Additionally, synergistic interaction was noted between p-YAP positivity and nuclear β-catenin on advanced adenomas (OR = 16.82, 95% CI = 4.41-64.08, P < .0001). YAP-correlated genes were significantly enriched in autophagy, unfolded protein response, and sirtuin pathways showing predominantly pro-tumorigenic alterations. Collectively, YAP plays an oncogenic role in interacting with Wnt as well as other cancer pathways within human sporadic adenomas. P-YAP could be a potential biomarker for human high-risk sporadic adenomas.","journal":"Carcinogenesis","year":2025,"id":540416,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9674,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":240064,"name":"Xingyi Guo","orcid":"0000-0001-5269-1294","position":1,"is_corresponding":false},{"id":86848,"name":"M. Kay Washington","orcid":"0000-0002-9589-7695","position":2,"is_corresponding":false},{"id":292844,"name":"Jiajun Shi","orcid":"0000-0001-5194-0009","position":3,"is_corresponding":false},{"id":499224,"name":"Reid M. Ness","orcid":"0000-0002-1645-7393","position":4,"is_corresponding":false},{"id":1428188,"name":"Qi Liu","orcid":"0000-0002-5576-8469","position":5,"is_corresponding":false},{"id":259911,"name":"Wanqing Wen","orcid":"0000-0002-3004-5168","position":6,"is_corresponding":false},{"id":385973,"name":"Shuya Huang","orcid":"0000-0001-6226-7817","position":7,"is_corresponding":false},{"id":1428189,"name":"Xiao Liu","orcid":"0000-0002-5363-6331","position":8,"is_corresponding":false},{"id":86849,"name":"Qiuyin Cai","orcid":"0000-0002-9384-5648","position":9,"is_corresponding":false},{"id":39347,"name":"Wei Zheng","orcid":"0000-0003-1226-070X","position":10,"is_corresponding":false},{"id":86857,"name":"Robert J. Coffey","orcid":"0000-0002-2180-3844","position":11,"is_corresponding":false},{"id":86858,"name":"Martha J. Shrubsole","orcid":"0000-0002-5591-7575","position":12,"is_corresponding":false},{"id":86853,"name":"Timothy Su","orcid":"0000-0002-7831-1947","position":13,"is_corresponding":false},{"id":1131795,"name":"Lei Fan","orcid":"0000-0003-1091-7018","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:52:38.861025Z","pmid":"39977302","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}