{"doi":"10.1093/carcin/bgab012","title":"Circadian disruption in mice through chronic jet lag-like conditions modulates molecular profiles of cancer in nucleus accumbens and prefrontal cortex","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Biological rhythms regulate physiological activities. Shiftwork disrupts normal circadian rhythms and may increase the risk of cancer through unknown mechanisms. To mimic environmental light/dark changes encountered by shift workers, a protocol called ‘chronic jet lag (CJL)’ induced by repeatedly shifting light–dark cycles has been used. Here, we subjected mice to CJL by advancing light–dark cycle by 6 h every 2 days, and conducted RNA sequencing to analyze the expression profile and molecular signature in the brain areas of prefrontal cortex and nucleus accumbens. We also performed positron emission tomography (PET) imaging to monitor changes related to glucose metabolism in brain. Our results reveal systematic reprogramming of gene expression associated with cancer-related pathways and metabolic pathways in prefrontal cortex and nucleus accumbens. PET imaging indicates that glucose uptake level was significantly reduced in whole brain as well as the individual brain regions. Moreover, qPCR analysis describes that the expression levels of cancer-related genes were altered in prefrontal cortex and nucleus accumbens. Overall, these results suggest a molecular and metabolic link with CJL-mediated cancer risk, and generate hypotheses on how CJL increases the susceptibility to cancer.</jats:p>","journal":"Carcinogenesis","year":2021,"id":30776,"datarank":0.5890023345799086,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.22931804366015293,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.22931804366015293,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":7,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":166454,"name":"V Wee Yong","orcid":"0000-0002-2600-3563","position":1,"is_corresponding":false},{"id":166455,"name":"Mengzhou Xue","orcid":null,"position":2,"is_corresponding":false},{"id":166453,"name":"Suliman Khan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33608694","pmcid":null,"openalex_id":"https://openalex.org/W3132610554","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82071331","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81870942","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81520108011","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2018YFC1312200","title":null},{"funder_name":"China Postdoctoral Science Foundation","grant_id":"2020M672291","title":null},{"funder_name":"Canadian Institutes of Health Sciences","grant_id":"","title":null}],"total_grants":6,"fwci":0.8544,"citation_percentile":0.67619048,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model","oa_locations":[{"url":"https://academic.oup.com/carcin/article-pdf/42/6/864/38711297/bgab012.pdf","host_type":"journal"},{"url":"https://academic.oup.com/carcin/article-pdf/42/6/864/38711297/bgab012.pdf","host_type":"BRONZE"},{"url":"https://academic.oup.com/carcin/article-pdf/42/6/864/38711297/bgab012.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/carcin/advance-article-pdf/doi/10.1093/carcin/bgab012/38499237/bgab012.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/carcin/article-pdf/42/6/864/38711297/bgab012.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/carcin/bgab012","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33608694","host_type":"repository"}],"fields_of_study":["Circadian rhythm and melatonin","Spaceflight effects on biology","Adipose Tissue and Metabolism","Medicine","Biology","Environmental Science","Animals","Biomarkers, Tumor","Brain Neoplasms","Chronic Disease","Disease Models, Animal","Gene Expression Regulation, Neoplastic","Jet Lag Syndrome","Male","Mice","Mice, Inbred C57BL","Nucleus Accumbens","Photoperiod","Prefrontal Cortex","RNA-Seq"],"mesh_terms":["RNA-Seq","Animals","Brain Neoplasms","Chronic Disease","Disease Models, Animal","Male","Mice, Inbred C57BL","Nucleus Accumbens","Biomarkers, Tumor","Gene Expression Regulation, Neoplastic","Prefrontal Cortex","Photoperiod","Jet Lag Syndrome","Mice"],"keywords":["Nucleus accumbens","Prefrontal cortex","Neuroscience","Circadian rhythm","Biology","Internal medicine","Endocrinology","Medicine","Central nervous system"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T04:37:49.106872Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}