{"doi":"10.1093/brain/awv051","title":"Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self","abstract":null,"journal":"Brain","year":2015,"id":683973,"datarank":0.8386480470766287,"base_score":5.5909869805108565,"endowment":5.5909869805108565,"self_citation_contribution":0.8386480470766287,"citation_network_contribution":0.0,"self_endowment_contribution":0.8386480470766287,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":267,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":316786,"name":"Edmund T. Rolls","orcid":"0000-0003-3025-1292","position":1,"is_corresponding":false},{"id":1754618,"name":"Huaguang Gu","orcid":null,"position":2,"is_corresponding":false},{"id":322630,"name":"Jie Zhang","orcid":"0000-0002-9941-1568","position":3,"is_corresponding":false},{"id":60715,"name":"Jianfeng Feng","orcid":null,"position":4,"is_corresponding":false},{"id":611096,"name":"Wei Cheng","orcid":"0000-0001-5456-626X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self","abstract":"Whole-brain voxel-based unbiased resting state functional connectivity was analysed in 418 subjects with autism and 509 matched typically developing individuals. We identified a key system in the middle temporal gyrus/superior temporal sulcus region that has reduced cortical functional connectivity (and increased with the medial thalamus), which is implicated in face expression processing involved in social behaviour. This system has reduced functional connectivity with the ventromedial prefrontal cortex, which is implicated in emotion and social communication. The middle temporal gyrus system is also implicated in theory of mind processing. We also identified in autism a second key system in the precuneus/superior parietal lobule region with reduced functional connectivity, which is implicated in spatial functions including of oneself, and of the spatial environment. It is proposed that these two types of functionality, face expression-related, and of one’s self and the environment, are important components of the computations involved in theory of mind, whether of oneself or of others, and that reduced connectivity within and between these regions may make a major contribution to the symptoms of autism. Cheng, Rolls et al. examine whole-brain voxel-based resting-state functional connectivity in 418 people with autism. They reveal reduced connectivity between regions involved in facial expression processing and theory of mind (middle temporal gyrus), emotion processing (ventromedial prefrontal cortex), and the representation of self (precuneus and related posterior cingulate areas).","is_dataset_classified":null,"base_score":5.5909869805108565,"endowment":5.5909869805108565,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25795704","pmcid":"PMC4407191","openalex_id":"https://openalex.org/W2104482304","authors":[],"funders":[],"total_grants":0,"fwci":13.8148,"citation_percentile":0.99420942,"influential_citations":0,"citation_trend":[{"year":2015,"count":7},{"year":2016,"count":25},{"year":2017,"count":22},{"year":2018,"count":39},{"year":2019,"count":32},{"year":2020,"count":21},{"year":2021,"count":33},{"year":2022,"count":21},{"year":2023,"count":20},{"year":2024,"count":25},{"year":2025,"count":13},{"year":2026,"count":9}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://academic.oup.com/brain/article-pdf/138/5/1382/13799827/awv051.pdf","host_type":"journal"},{"url":"https://academic.oup.com/brain/article-pdf/138/5/1382/13799827/awv051.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/brain/article-pdf/138/5/1382/13799827/awv051.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/brain/awv051","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25795704","host_type":"repository"},{"url":"http://wrap.warwick.ac.uk/65504/7/WRAP_awv051.pdf","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.706.8634","host_type":""},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4407191","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4407191","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4407191?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Autism Spectrum Disorder Research","Child and Animal Learning Development","Face Recognition and Perception"],"mesh_terms":["Autistic Disorder","Brain Mapping","Emotions","Facial Expression","Humans","Image Processing, Computer-Assisted","Magnetic Resonance Imaging","Neural Pathways","Neuropsychological Tests","Temporal Lobe","Theory of Mind"],"keywords":["Precuneus","Middle temporal gyrus","Ventromedial prefrontal cortex","Superior temporal sulcus","Psychology","Neuroscience","Autism","Theory of mind","Prefrontal cortex","Posterior cingulate","Fusiform face area","Inferior parietal lobule","Resting state fMRI","Superior temporal gyrus","Facial expression","Temporal cortex","Cognitive psychology","Functional magnetic resonance imaging","Face perception","Perception","Cognition","Developmental psychology","Communication","Temporal lobe","Autistic Spectrum Disorder","Behavioural Neurology","Neuropsychiatry Imaging Social Cognition"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.14583638.v1","title":"Additional file 1 of Impairments in brain perfusion, executive control network, topological characteristics, and neurocognition in adult patients with asymptomatic Moyamoya disease","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14583638","title":"Additional file 1 of Impairments in brain perfusion, executive control network, topological characteristics, and neurocognition in adult patients with asymptomatic Moyamoya disease","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.16614305.v1","title":"Additional file 1 of Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.16614305","title":"Additional file 1 of Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T12:56:04.633140Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}