{"doi":"10.1093/brain/awt322","title":"Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease","abstract":null,"journal":"Brain","year":2014,"id":636619,"datarank":0.7862620522589465,"base_score":5.241747015059643,"endowment":5.241747015059643,"self_citation_contribution":0.7862620522589465,"citation_network_contribution":0.0,"self_endowment_contribution":0.7862620522589465,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":188,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":654450,"name":"Andreas Buchmann","orcid":null,"position":1,"is_corresponding":false},{"id":1010817,"name":"Cornelia Hagmann","orcid":"0000-0003-2647-9809","position":2,"is_corresponding":false},{"id":200903,"name":"Reto Huber","orcid":null,"position":3,"is_corresponding":false},{"id":1652443,"name":"Peter Klaver","orcid":null,"position":4,"is_corresponding":false},{"id":1652447,"name":"Walter Knirsch","orcid":null,"position":5,"is_corresponding":false},{"id":616221,"name":"Beatrice Latal","orcid":"0000-0003-1309-4790","position":6,"is_corresponding":false},{"id":1652438,"name":"Michael von Rhein","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease","abstract":"Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evidence suggests that brain maturation can be delayed and pre- and postoperative brain injury may occur, and there is limited information on the long-term effect of congenital heart disease on brain development and function in adolescent patients. At a mean age of 13.8 years, 39 adolescent survivors of childhood cardiopulmonary bypass surgery with no structural brain lesions evident through conventional cerebral magnetic resonance imaging and 32 healthy control subjects underwent extensive neurodevelopmental assessment and cerebral magnetic resonance imaging. Cerebral scans were analysed quantitatively using surface-based and voxel-based morphometry. Compared with control subjects, patients had lower total brain (P = 0.003), white matter (P = 0.004) and cortical grey matter (P = 0.005) volumes, whereas cerebrospinal fluid volumes were not different. Regional brain volume reduction ranged from 5.3% (cortical grey matter) to 11% (corpus callosum). Adolescents with cyanotic heart disease showed more brain volume loss than those with acyanotic heart disease, particularly in the white matter, thalami, hippocampi and corpus callosum (all P-values < 0.05). Brain volume reduction correlated significantly with cognitive, motor and executive functions (grey matter: P < 0.05, white matter: P < 0.01). Our findings suggest that there are long-lasting cerebral changes in adolescent survivors of cardiopulmonary bypass surgery for congenital heart disease and that these changes are associated with functional outcome.","is_dataset_classified":null,"base_score":5.241747015059643,"endowment":5.241747015059643,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24277720","pmcid":null,"openalex_id":"https://openalex.org/W2036816774","authors":[],"funders":[{"funder_name":"Swiss National Science Foundation","grant_id":"127115","title":"Common neural mechanisms of working memory and episodic memory in typical and atypical development"}],"total_grants":1,"fwci":6.9716,"citation_percentile":0.97645183,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":14},{"year":2016,"count":20},{"year":2017,"count":11},{"year":2018,"count":16},{"year":2019,"count":22},{"year":2020,"count":20},{"year":2021,"count":16},{"year":2022,"count":23},{"year":2023,"count":13},{"year":2024,"count":12},{"year":2025,"count":10},{"year":2026,"count":9}],"oa_status":"bronze","license":"other-oa","oa_locations":[{"url":"https://academic.oup.com/brain/article-pdf/137/1/268/13797069/awt322.pdf","host_type":"journal"},{"url":"https://academic.oup.com/brain/article-pdf/137/1/268/13797069/awt322.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/brain/article-pdf/137/1/268/13797069/awt322.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/brain/awt322","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24277720","host_type":"repository"},{"url":"http://www.ncbi.nlm.nih.gov/pubmed/24277720","host_type":"journal"},{"url":"http://epubs.surrey.ac.uk/828699/","host_type":"repository"},{"url":"https://doi.org/10.5167/uzh-89520","host_type":""},{"url":"https://dx.doi.org/10.5167/uzh-89520","host_type":""},{"url":"https://dx.doi.org/10.1093/brain/awt322","host_type":""},{"url":"https://sonar.ch/global/documents/211753","host_type":""},{"url":"https://openresearch.surrey.ac.uk/esploro/outputs/journalArticle/Brain-volumes-predict-neurodevelopment-in-adolescents/99516253302346","host_type":""},{"url":"https://www.zora.uzh.ch/id/eprint/89520/","host_type":""},{"url":"http://dx.doi.org/10.1093/brain/awt322","host_type":""},{"url":"https://doi.org/https://doi.org/10.1093/brain/awt322","host_type":""}],"fields_of_study":["Congenital Heart Disease Studies","Coronary Artery Anomalies","Aortic Disease and Treatment Approaches","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Adolescent","Brain","Child","Cognition","Cyanosis","Female","Heart Defects, Congenital","Cardiac Surgical Procedures","Humans","Image Processing, Computer-Assisted","Magnetic Resonance Imaging","Male","Neurologic Examination","Neuropsychological Tests","Predictive Value of Tests","Psychomotor Performance","Risk Factors","Adolescent Development"],"keywords":["Grey matter","Corpus callosum","White matter","Medicine","Magnetic resonance imaging","Brain size","Cardiology","Brain Structure and Function","Heart disease","Cardiopulmonary bypass","Brain morphometry","Neuroimaging","Voxel-based morphometry","Internal medicine","Pathology","Radiology","Psychiatry","Neurodevelopment","Congenital heart disease","Adolescents","Brain Volume","Cardiopulmonary Bypass Surgery","Heart Defects, Congenital","Male","Adolescent","Image Processing","610","610 Medicine & health","Neuropsychological Tests","Congenital","Computer-Assisted","Cognition","Predictive Value of Tests","Risk Factors","11554 Zurich Center for Integrative Human Physiology (ZIHP)","616","10058 Child and Adolescent Psychiatry","Image Processing, Computer-Assisted","Humans","Cardiac Surgical Procedures","Child","610 Medicine &amp; health","Heart Defects","Cyanosis","Neurologic Examination","10093 Institute of Psychology","Brain","Adolescent Development","10027 Clinic for Neonatology","2728 Neurology (clinical)","10036 Medical Clinic","570 Life sciences; biology","Female","150 Psychology","Psychomotor Performance"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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