{"doi":"10.1093/brain/awae325","title":"Amyloid-β predominant Alzheimer’s disease neuropathologic change","abstract":"Different subsets of Alzheimer's disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic and clinical features. Analysing National Alzheimer's Coordinating Center data, we stratified 1187 participants into AP-ADNC (n = 95), low Braak primary age-related tauopathy (PART; n = 185), typical-ADNC (n = 832) and high-Braak PART (n = 75). AP-ADNC differed in some clinical features and genetic polymorphisms in the APOE, SNX1, WNT3/MAPT and IGH genes. We conclude that AP-ADNC differs from classical ADNC with implications for in vivo studies.","journal":"Brain","year":2024,"id":427549,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7758,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244994,"name":"Yuriko Katsumata","orcid":"0000-0002-0188-8094","position":1,"is_corresponding":false},{"id":87214,"name":"Xian Wu","orcid":"0000-0003-1118-9710","position":2,"is_corresponding":false},{"id":1203874,"name":"Khine Zin Aung","orcid":"0009-0000-3793-6927","position":3,"is_corresponding":false},{"id":244999,"name":"David W. Fardo","orcid":"0000-0002-7207-4696","position":4,"is_corresponding":false},{"id":1036935,"name":"Shelley L. Forrest","orcid":"0000-0001-7863-5389","position":5,"is_corresponding":false},{"id":755697,"name":"James D. Bowen","orcid":"0000-0002-4258-250X","position":6,"is_corresponding":false},{"id":91756,"name":"Paul K. Crane","orcid":"0000-0003-4278-7465","position":7,"is_corresponding":false},{"id":251748,"name":"Gail P. Jarvik","orcid":"0000-0002-6710-8708","position":8,"is_corresponding":false},{"id":38380,"name":"C. Dirk Keene","orcid":"0000-0002-5291-1469","position":9,"is_corresponding":false},{"id":261050,"name":"Eric B. Larson","orcid":null,"position":10,"is_corresponding":false},{"id":614008,"name":"Wayne C. McCormick","orcid":null,"position":11,"is_corresponding":false},{"id":373970,"name":"Susan M. McCurry","orcid":"0000-0001-8624-3772","position":12,"is_corresponding":false},{"id":261837,"name":"Shubhabrata Mukherjee","orcid":"0000-0003-2522-2884","position":13,"is_corresponding":false},{"id":291833,"name":"Neil W. Kowall","orcid":"0000-0002-6624-0213","position":14,"is_corresponding":false},{"id":271280,"name":"Ann C. McKee","orcid":"0000-0003-2961-7488","position":15,"is_corresponding":false},{"id":304496,"name":"Robert A. Stern","orcid":"0000-0002-5008-077X","position":16,"is_corresponding":false},{"id":527891,"name":"Clinton T. Baldwin","orcid":null,"position":17,"is_corresponding":false},{"id":27609,"name":"Lindsay A. Farrer","orcid":"0000-0001-5533-4225","position":18,"is_corresponding":false},{"id":562002,"name":"Gyungah Jun","orcid":"0000-0002-3230-8697","position":19,"is_corresponding":false},{"id":24988,"name":"Kathryn L. Lunetta","orcid":"0000-0002-9268-810X","position":20,"is_corresponding":false},{"id":108602,"name":"Lawrence S. Honig","orcid":"0000-0002-9703-2265","position":21,"is_corresponding":false},{"id":7428,"name":"Jean Paul Vonsattel","orcid":null,"position":22,"is_corresponding":false},{"id":606786,"name":"Jennifer Williamson","orcid":"0000-0001-8216-5885","position":23,"is_corresponding":false},{"id":250242,"name":"Scott A. Small","orcid":"0000-0002-4777-1502","position":24,"is_corresponding":false},{"id":436117,"name":"Sandra Barral","orcid":"0000-0001-5623-4939","position":25,"is_corresponding":false},{"id":355816,"name":"Christiane Reitz","orcid":"0000-0001-8757-7889","position":26,"is_corresponding":false},{"id":63303,"name":"Badri N. Vardarajan","orcid":"0000-0002-5560-4085","position":27,"is_corresponding":false},{"id":27608,"name":"Richard Mayeux","orcid":"0000-0001-6519-9696","position":28,"is_corresponding":false},{"id":610014,"name":"James R. Burke","orcid":"0000-0002-3408-7787","position":29,"is_corresponding":false},{"id":889967,"name":"Christine M. Hulette","orcid":null,"position":30,"is_corresponding":false},{"id":325850,"name":"Kathleen A. Welsh‐Bohmer","orcid":"0000-0003-1824-0179","position":31,"is_corresponding":false},{"id":279012,"name":"Marla Gearing","orcid":"0000-0002-1959-7412","position":32,"is_corresponding":false},{"id":68013,"name":"James J. Lah","orcid":null,"position":33,"is_corresponding":false},{"id":68010,"name":"Allan I. Levey","orcid":"0000-0002-3153-502X","position":34,"is_corresponding":false},{"id":107092,"name":"Thomas S. Wingo","orcid":"0000-0002-7679-6282","position":35,"is_corresponding":false},{"id":278826,"name":"Liana G. Apostolova","orcid":"0000-0003-1823-2451","position":36,"is_corresponding":false},{"id":324301,"name":"Martin R. Farlow","orcid":"0000-0001-7897-5471","position":37,"is_corresponding":false},{"id":268832,"name":"Bernardino Ghetti","orcid":"0000-0002-1842-8019","position":38,"is_corresponding":false},{"id":27595,"name":"Andrew J. Saykin","orcid":"0000-0002-1376-8532","position":39,"is_corresponding":false},{"id":260466,"name":"Salvatore Spina","orcid":"0000-0003-3570-9143","position":40,"is_corresponding":false},{"id":253913,"name":"Kelley Faber","orcid":"0000-0003-3224-2736","position":41,"is_corresponding":false},{"id":66398,"name":"Tatiana M. Foroud","orcid":null,"position":42,"is_corresponding":false},{"id":19614,"name":"Marilyn Albert","orcid":"0000-0002-8167-8985","position":43,"is_corresponding":false},{"id":361062,"name":"Constantine G. Lyketsos","orcid":"0000-0003-3827-4720","position":44,"is_corresponding":false},{"id":107084,"name":"Juan C. Troncoso","orcid":"0000-0001-9553-6673","position":45,"is_corresponding":false},{"id":28993,"name":"Matthew P. Frosch","orcid":"0000-0002-3940-9861","position":46,"is_corresponding":false},{"id":32939,"name":"Robert C. Green","orcid":"0000-0001-8472-0424","position":47,"is_corresponding":false},{"id":423146,"name":"John H. Growdon","orcid":null,"position":48,"is_corresponding":false},{"id":19610,"name":"Bradley T. Hyman","orcid":"0000-0002-7959-9401","position":49,"is_corresponding":false},{"id":226532,"name":"Rudolph E. Tanzi","orcid":"0000-0002-7032-1454","position":50,"is_corresponding":false},{"id":417385,"name":"Huntington Potter","orcid":"0000-0002-4051-2516","position":51,"is_corresponding":false},{"id":54753,"name":"Dennis W. Dickson","orcid":"0000-0001-7189-7917","position":52,"is_corresponding":false},{"id":776,"name":"Nilüfer Ertekin‐Taner","orcid":"0000-0003-4436-8889","position":53,"is_corresponding":false},{"id":1228752,"name":"Neill R Graff-Radford","orcid":null,"position":54,"is_corresponding":false},{"id":681595,"name":"Joseph E. Parisi","orcid":"0000-0002-0215-9643","position":55,"is_corresponding":false},{"id":27599,"name":"Ronald C. Petersen","orcid":"0000-0002-8178-6601","position":56,"is_corresponding":false},{"id":843280,"name":"Bradley F Boeve","orcid":null,"position":57,"is_corresponding":false},{"id":232915,"name":"Mariet Allen","orcid":"0000-0002-2685-427X","position":58,"is_corresponding":false},{"id":308849,"name":"Minerva M. Carrasquillo","orcid":"0000-0002-3231-9134","position":59,"is_corresponding":false},{"id":230888,"name":"Steven G. Younkin","orcid":"0000-0002-7818-3105","position":60,"is_corresponding":false},{"id":66588,"name":"Ranjan Duara","orcid":null,"position":61,"is_corresponding":false},{"id":35461,"name":"Joseph D. Buxbaum","orcid":"0000-0001-8898-8313","position":62,"is_corresponding":false},{"id":27629,"name":"Alison Goate","orcid":"0000-0002-0576-2472","position":63,"is_corresponding":false},{"id":284623,"name":"Mary Sano","orcid":"0000-0001-8889-2944","position":64,"is_corresponding":false},{"id":476806,"name":"Arjun V. Masurkar","orcid":"0000-0002-2498-2059","position":65,"is_corresponding":false},{"id":231338,"name":"Thomas Wısnıewskı","orcid":"0000-0002-3379-8966","position":66,"is_corresponding":false},{"id":308296,"name":"Eileen H. Bigio","orcid":"0000-0002-9554-1138","position":67,"is_corresponding":false},{"id":455455,"name":"Marsel Mesulam","orcid":"0000-0001-5731-851X","position":68,"is_corresponding":false},{"id":49969,"name":"Sandra Weıntraub","orcid":"0000-0003-2605-5205","position":69,"is_corresponding":false},{"id":230263,"name":"Robert Vassar","orcid":"0000-0002-1358-504X","position":70,"is_corresponding":false},{"id":55003,"name":"Jeffrey Kaye","orcid":"0000-0002-9971-3478","position":71,"is_corresponding":false},{"id":226068,"name":"Joseph F. Quinn","orcid":"0000-0001-7305-2256","position":72,"is_corresponding":false},{"id":300187,"name":"Randall L. Woltjer","orcid":null,"position":73,"is_corresponding":false},{"id":325844,"name":"Lisa L. Barnes","orcid":"0000-0002-0072-9817","position":74,"is_corresponding":false},{"id":901792,"name":"Lei Yu","orcid":"0000-0002-4235-9033","position":75,"is_corresponding":false},{"id":248323,"name":"Denis A. Evans","orcid":null,"position":76,"is_corresponding":false},{"id":355540,"name":"Victor W. Henderson","orcid":"0000-0003-1198-9240","position":77,"is_corresponding":false},{"id":889965,"name":"Kenneth B. Fallon","orcid":null,"position":78,"is_corresponding":false},{"id":889966,"name":"Lindy E. Harrell","orcid":null,"position":79,"is_corresponding":false},{"id":325847,"name":"Daniel Marson","orcid":"0000-0002-4867-3234","position":80,"is_corresponding":false},{"id":246148,"name":"Erik D. Roberson","orcid":"0000-0002-1810-9763","position":81,"is_corresponding":false},{"id":66359,"name":"Charles DeCarli","orcid":null,"position":82,"is_corresponding":false},{"id":276105,"name":"Lee‐Way Jin","orcid":null,"position":83,"is_corresponding":false},{"id":303071,"name":"John Olichney","orcid":null,"position":84,"is_corresponding":false},{"id":834149,"name":"Ronald Kim","orcid":"0000-0003-3298-9653","position":85,"is_corresponding":false},{"id":315609,"name":"Frank M. LaFerla","orcid":"0000-0003-2324-6911","position":86,"is_corresponding":false},{"id":504626,"name":"Edwin S. Monuki","orcid":"0000-0001-5130-781X","position":87,"is_corresponding":false},{"id":270466,"name":"Elizabeth Head","orcid":"0000-0003-1115-6396","position":88,"is_corresponding":false},{"id":286072,"name":"David L. Sultzer","orcid":"0009-0006-5264-5611","position":89,"is_corresponding":false},{"id":21398,"name":"Daniel H. Geschwind","orcid":"0000-0003-2896-3450","position":90,"is_corresponding":false},{"id":244990,"name":"Harry V. Vinters","orcid":"0000-0002-2965-1240","position":91,"is_corresponding":false},{"id":698346,"name":"Marie‐Françoise Chesselet","orcid":"0000-0002-1202-1226","position":92,"is_corresponding":false},{"id":108599,"name":"Douglas Galasko","orcid":"0000-0001-6195-3241","position":93,"is_corresponding":false},{"id":66463,"name":"James Brewer","orcid":null,"position":94,"is_corresponding":false},{"id":253908,"name":"Adam L. Boxer","orcid":"0000-0002-1215-5064","position":95,"is_corresponding":false},{"id":256789,"name":"Anna Karydas","orcid":null,"position":96,"is_corresponding":false},{"id":330926,"name":"Joel H. Kramer","orcid":"0000-0002-1206-404X","position":97,"is_corresponding":false},{"id":58513,"name":"Bruce L. Miller","orcid":"0000-0002-2152-4220","position":98,"is_corresponding":false},{"id":67119,"name":"Howard J. Rosen","orcid":null,"position":99,"is_corresponding":false},{"id":227415,"name":"Gábor G. Kovács","orcid":"0000-0003-3841-5511","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:52.576447Z","pmid":"39417691","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}