{"doi":"10.1093/brain/awac270","title":"COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis","abstract":"Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with acute and postacute cognitive and neuropsychiatric symptoms including impaired memory, concentration, attention, sleep and affect. Mechanisms underlying these brain symptoms remain understudied. Here we report that SARS-CoV-2-infected hamsters exhibit a lack of viral neuroinvasion despite aberrant blood-brain barrier permeability. Hamsters and patients deceased from coronavirus disease 2019 (COVID-19) also exhibit microglial activation and expression of interleukin (IL)-1β and IL-6, especially within the hippocampus and the medulla oblongata, when compared with non-COVID control hamsters and humans who died from other infections, cardiovascular disease, uraemia or trauma. In the hippocampal dentate gyrus of both COVID-19 hamsters and humans, we observed fewer neuroblasts and immature neurons. Protracted inflammation, blood-brain barrier disruption and microglia activation may result in altered neurotransmission, neurogenesis and neuronal damage, explaining neuropsychiatric presentations of COVID-19. The involvement of the hippocampus may explain learning, memory and executive dysfunctions in COVID-19 patients.","journal":"Brain","year":2022,"id":232655,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":176,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106936,"name":"Abigail Vanderheiden","orcid":"0000-0003-1321-4510","position":1,"is_corresponding":false},{"id":104003,"name":"Anna S. Nordvig","orcid":"0000-0003-3360-9157","position":2,"is_corresponding":false},{"id":845016,"name":"Cheick A Sissoko","orcid":null,"position":3,"is_corresponding":false},{"id":107943,"name":"Peter Canoll","orcid":"0000-0002-7001-0226","position":4,"is_corresponding":false},{"id":803921,"name":"Madeline B. Mariani","orcid":"0009-0006-8183-1173","position":5,"is_corresponding":false},{"id":843758,"name":"Xiaoping Jiang","orcid":"0000-0002-1702-2893","position":6,"is_corresponding":false},{"id":553176,"name":"Traci L. Bricker","orcid":null,"position":7,"is_corresponding":false},{"id":686537,"name":"Gorazd Rosoklija","orcid":"0000-0003-2711-1694","position":8,"is_corresponding":false},{"id":439651,"name":"Victoria Arango","orcid":"0000-0001-8811-400X","position":9,"is_corresponding":false},{"id":326695,"name":"Mark D. Underwood","orcid":"0000-0003-0595-8712","position":10,"is_corresponding":false},{"id":6272,"name":"J. John Mann","orcid":"0000-0002-0265-6586","position":11,"is_corresponding":false},{"id":686538,"name":"Andrew J. Dwork","orcid":"0000-0002-9862-0384","position":12,"is_corresponding":false},{"id":296382,"name":"James E. Goldman","orcid":"0000-0003-2135-8936","position":13,"is_corresponding":false},{"id":334926,"name":"Adrianus C. M. Boon","orcid":"0000-0002-4700-8224","position":14,"is_corresponding":false},{"id":6253,"name":"Maura Boldrini","orcid":"0000-0003-3574-7641","position":15,"is_corresponding":false},{"id":230439,"name":"Robyn S. Klein","orcid":"0000-0003-0281-1352","position":16,"is_corresponding":false},{"id":552253,"name":"Allison Soung","orcid":"0000-0002-1590-6038","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T00:21:18.683916Z","pmid":"36004663","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}