{"doi":"10.1093/bjd/ljae452","title":"R(+) propranolol decreases lipid accumulation in haemangioma-derived stem cells","abstract":"Infantile haemangioma (IH), often treated with propranolol, is a benign vascular tumour that undergoes a spontaneous involution to a fibrofatty residuum. We investigated how R(+) propranolol, the nonbeta blocker enantiomer of racaemic propranolol, affects lipid accumulation and adipogenesis in IH. This was motivated by our previous work showing that R(+) propranolol can block blood vessel formation in a preclinical model of IH. Our findings suggest a novel regulatory role for R(+) propranolol in modulating lipid accumulation in haemangioma stem cells. This highlights a novel role for R(+) propranolol in the involuting phase of IH and offers a strategy to reduce fibrofatty residua in IH.","journal":"British Journal of Dermatology","year":2024,"id":477989,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":459583,"name":"Jill Wylie‐Sears","orcid":"0000-0003-3305-8578","position":1,"is_corresponding":false},{"id":652536,"name":"Caroline T. Seebauer","orcid":null,"position":2,"is_corresponding":false},{"id":439156,"name":"John B. Mulliken","orcid":null,"position":3,"is_corresponding":false},{"id":499669,"name":"Mathias François","orcid":"0000-0002-9846-6882","position":4,"is_corresponding":false},{"id":1206097,"name":"Annegret Holm","orcid":"0000-0002-8691-4131","position":5,"is_corresponding":false},{"id":381507,"name":"Joyce Bischoff","orcid":"0000-0002-6367-1974","position":6,"is_corresponding":false},{"id":1316523,"name":"J. Tan","orcid":"0009-0000-1901-7070","position":0,"is_corresponding":true}],"reference_count":8,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:06:42.155024Z","pmid":"39565162","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}