{"doi":"10.1093/biolreprod/85.s1.449","title":"Expression of Calcium Transport Genes in the Placenta of Calbindin-D9k and -D28k Knockout Mice.","abstract":null,"journal":"Biology of Reproduction","year":2011,"id":683778,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1671099,"name":"Hyun Yang","orcid":null,"position":1,"is_corresponding":false},{"id":1786296,"name":"Eui-Bae Jeung","orcid":null,"position":2,"is_corresponding":false},{"id":1786295,"name":"Tae-Hyoung Koo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Expression of Calcium Transport Genes in the Placenta of Calbindin-D9k and -D28k Knockout Mice.","abstract":"During pregnancy, the placenta represents the establishment of an intimate connection between mother and fetus that is specific to mammals. Calbindin-D9k (CaBP-9k), -D28k (CaBP-28k) are proteins possessing EF-hand motifs which have a high affinity for Ca2+ ions. Many types of calcium channel, intracellular calcium binding proteins, Na+/Ca2+ exchangers (NCX), transient receptor potential cation channels (TRPV) were found in placenta. In this study, the calcium channel in maternal-fetal Ca2+ transport was investigated in wild-type, CaBP-9k, CaBP-28k and CaBP-9k/28k knockout (KO) mouse models. Expressions of calcium transport genes in three dissected sections of placenta (MP: maternal-, CP: central-, FP: fetal-) were examined at gestational day 19 (GD 19) in these mice. The expression of TRPV6 mRNA and protein was highest in CaBP-28k KO mice at MP and CP compared with other KO mice, or CaBP-9k KO mice at FP. The level of CaBP-9k expression was significantly induced in CaBP-28k KO mice at MP and CP, but not altered at FP. In addition, the expression of CaBP-28k mRNA and protein were reduced in CaBP-9k KO mice than WT in all sections of placenta. These results indicate that TRPV6 participates in transferring calcium ions between maternal and fetal compartments and alteration of CaBP-9k/28k is involved in intracellular Ca2+ buffering system among single and double KO mice. Taken together, TRPV6 and CaBP-9k gene may play a role as a key element in controlling calcium transport in the placenta during pregnancy. (poster)","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W2592913894","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/biolreprod/article-pdf/85/Suppl_1/449/","host_type":"publisher"},{"url":"https://doi.org/10.1093/biolreprod/85.s1.449","host_type":"journal"}],"fields_of_study":["Birth, Development, and Health"],"mesh_terms":[],"keywords":["Calbindin","TRPV6","Placenta","Calcium","Calcium-binding protein","Internal medicine","Endocrinology","Biology","Knockout mouse","Vitamin D-dependent calcium-binding protein","Calcium metabolism","Fetus","Receptor","Biochemistry","Pregnancy","Genetics","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T12:07:42.571856Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}