{"doi":"10.1093/bioinformatics/btae103","title":"HIResist: a database of HIV-1 resistance to broadly neutralizing antibodies","abstract":"MOTIVATION: Changing the course of the human immunodeficiency virus type I (HIV-1) pandemic is a high public health priority with approximately 39 million people currently living with HIV-1 (PLWH) and about 1.5 million new infections annually worldwide. Broadly neutralizing antibodies (bnAbs) typically target highly conserved sites on the HIV-1 envelope glycoproteins (Envs), which mediate viral entry, and block the infection of diverse HIV-1 strains. But different mechanisms of HIV-1 resistance to bnAbs prevent robust application of bnAbs for therapeutic and preventive interventions. RESULTS: Here we report the development of a new database that provides data and computational tools to aid the discovery of resistant features and may assist in analysis of HIV-1 resistance to bnAbs. Bioinformatic tools allow identification of specific patterns in Env sequences of resistant strains and development of strategies to elucidate the mechanisms of HIV-1 escape; comparison of resistant and sensitive HIV-1 strains for each bnAb; identification of resistance and sensitivity signatures associated with specific bnAbs or groups of bnAbs; and visualization of antibody pairs on cross-sensitivity plots. The database has been designed with a particular focus on user-friendly and interactive interface. Our database is a valuable resource for the scientific community and provides opportunities to investigate patterns of HIV-1 resistance and to develop new approaches aimed to overcome HIV-1 resistance to bnAbs. AVAILABILITY AND IMPLEMENTATION: HIResist is freely available at https://hiresist.ahc.umn.edu/.","journal":"Bioinformatics","year":2024,"id":462933,"datarank":0.33367329956337,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.021757068311394588,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.021757068311394588,"corpus_percentile":48.193703102034505,"corpus_rank":6698,"citation_count":7,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.87,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1171018,"name":"Jeffy Jeffy","orcid":null,"position":1,"is_corresponding":false},{"id":1293258,"name":"Charis Liao","orcid":null,"position":2,"is_corresponding":false},{"id":1171021,"name":"Stephanie Pickthorn","orcid":null,"position":3,"is_corresponding":false},{"id":268925,"name":"Kshitij Wagh","orcid":"0000-0001-7552-6582","position":4,"is_corresponding":false},{"id":409389,"name":"Alon Herschhorn","orcid":"0000-0002-9323-4820","position":5,"is_corresponding":false},{"id":1293257,"name":"Milind Misra","orcid":null,"position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:04:24.680035Z","pmid":"38426331","pmcid":"PMC10919947","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}