{"doi":"10.1093/bioinformatics/btaa951","title":"MiRKAT: kernel machine regression-based global association tests for the microbiome","abstract":"SUMMARY: Distance-based tests of microbiome beta diversity are an integral part of many microbiome analyses. MiRKAT enables distance-based association testing with a wide variety of outcome types, including continuous, binary, censored time-to-event, multivariate, correlated and high-dimensional outcomes. Omnibus tests allow simultaneous consideration of multiple distance and dissimilarity measures, providing higher power across a range of simulation scenarios. Two measures of effect size, a modified R-squared coefficient and a kernel RV coefficient, are incorporated to allow comparison of effect sizes across multiple kernels. AVAILABILITY AND IMPLEMENTATION: MiRKAT is available on CRAN as an R package. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.","journal":"Bioinformatics","year":2020,"id":60465,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":62,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":36362,"name":"Ni Zhao","orcid":"0000-0002-7762-3949","position":1,"is_corresponding":false},{"id":318787,"name":"Xiang Zhan","orcid":"0000-0001-9650-143X","position":2,"is_corresponding":false},{"id":318788,"name":"Hyunwook Koh","orcid":"0000-0001-6893-7164","position":3,"is_corresponding":false},{"id":48394,"name":"Weijia Fu","orcid":"0009-0002-5955-3534","position":4,"is_corresponding":false},{"id":318789,"name":"Jun Chen","orcid":"0000-0003-4263-0759","position":5,"is_corresponding":false},{"id":18062,"name":"Hongzhe Li","orcid":"0000-0003-3662-3907","position":6,"is_corresponding":false},{"id":318790,"name":"Michael C. Wu","orcid":"0000-0002-3357-6570","position":7,"is_corresponding":false},{"id":318791,"name":"Anna Plantinga","orcid":"0000-0001-6281-7727","position":8,"is_corresponding":false},{"id":319570,"name":"Nehemiah Wilson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-18T21:08:47.852401Z","pmid":"33225342","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}