{"doi":"10.1093/bioinformatics/btaa276","title":"aPCoA: covariate adjusted principal coordinates analysis","abstract":"SUMMARY: In fields, such as ecology, microbiology and genomics, non-Euclidean distances are widely applied to describe pairwise dissimilarity between samples. Given these pairwise distances, principal coordinates analysis is commonly used to construct a visualization of the data. However, confounding covariates can make patterns related to the scientific question of interest difficult to observe. We provide adjusted principal coordinates analysis as an easy-to-use tool, available as both an R package and a Shiny app, to improve data visualization in this context, enabling enhanced presentation of the effects of interest. AVAILABILITY AND IMPLEMENTATION: The R package 'aPCoA' and Shiny app can be accessed at https://cran.r-project.org/web/packages/aPCoA/index.html and https://biostatistics.mdanderson.org/shinyapps/aPCoA/.","journal":"Bioinformatics","year":2020,"id":59385,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9604,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":312281,"name":"Liangliang Zhang","orcid":"0000-0001-5986-2260","position":1,"is_corresponding":false},{"id":246236,"name":"Kim‐Anh Do","orcid":"0000-0001-8710-7131","position":2,"is_corresponding":false},{"id":295093,"name":"Christine B. Peterson","orcid":"0000-0003-3316-0468","position":3,"is_corresponding":false},{"id":90471,"name":"Robert R. Jenq","orcid":"0000-0002-5434-439X","position":4,"is_corresponding":false},{"id":312280,"name":"Yushu Shi","orcid":"0000-0001-7575-9706","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-18T21:07:59.189921Z","pmid":"32339223","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}