{"doi":"10.1093/bioinformatics/8.4.367","title":"Analysis of context of 5′-splice site sequences in mammalian mRNA precursors by subclass method","abstract":null,"journal":"Bioinformatics","year":1992,"id":599426,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1536237,"name":"Sumie Kitamura-Abe","orcid":null,"position":1,"is_corresponding":false},{"id":1536238,"name":"Masaru Shimbo","orcid":null,"position":2,"is_corresponding":false},{"id":1536239,"name":"Yôichi lida","orcid":null,"position":3,"is_corresponding":false},{"id":1536236,"name":"Mineichi Kudo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Analysis of context of 5′-splice site sequences in mammalian mRNA precursors by subclass method","abstract":"The signals that direct the excision of introns from mammalian pre-mRNA are not yet well understood. However, at least three kinds of signals--5'-splice site signals, 3'-splice site signals and branch point signals--play important roles in the excision of introns. In the present paper we treat only the 5'-splice sites. In addition to a consensus sequence for 5'-splice signals, several methods have been proposed, based on a statistical model, and used to analyze relative importance of each nucleotide at each position. In our approach a nucleotide sequence is regarded as a string with symbols of 'A', 'T', 'G' and 'C'; important substrings of 5'-splice site sequences, called pattern sequences, are extracted. A pattern sequence expresses which nucleotide is needed at a limited number of positions around the 5'-splice site. It is observed that a particular pattern sequence matches predominantly 5'-splice site sequences nearest to the 5'-end of a gene and another pattern sequence matches predominantly the second nearest ones. Moreover, it is confirmed that the pattern sequences accurately predict authentic 5'-splice sites for unknown genes and explain some mutation examples.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1498692","pmcid":null,"openalex_id":"https://openalex.org/W1977098136","authors":[],"funders":[],"total_grants":0,"fwci":0.1433,"citation_percentile":0.40578104,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/bioinformatics/article-pdf/8/4/367/629419/8-4-367.pdf","host_type":"journal"},{"url":"https://academic.oup.com/bioinformatics/article-pdf/8/4/367/629419/8-4-367.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/bioinformatics/article-pdf/8/4/367/629419/8-4-367.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/bioinformatics/8.4.367","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1498692","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","RNA and protein synthesis mechanisms","Molecular Biology Techniques and Applications","Algorithms","Animals","Base Sequence","Mammals","Molecular Sequence Data","Mutation","Pattern Recognition, Automated","RNA Splicing"],"mesh_terms":["Algorithms","Animals","Base Sequence","Mammals","Molecular Sequence Data","Mutation","Pattern Recognition, Automated","RNA Splicing"],"keywords":["splice","Splice site mutation","Intron","Sequence (biology)","Genetics","RNA splicing","Biology","Context (archaeology)","Computational biology","Consensus sequence","Substring","Gene","Nucleic acid sequence","Alternative splicing","Exon","Computer science","RNA","Peptide sequence"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T04:40:51.464702Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}