{"doi":"10.1093/bioadv/vbae008","title":"HIVseqDB: a portable resource for NGS and sample metadata integration for HIV-1 drug resistance analysis","abstract":"Summary: Human immunodeficiency virus (HIV) remains a public health threat, with drug resistance being a major concern in HIV treatment. Next-generation sequencing (NGS) is a powerful tool for identifying low-abundance drug resistance mutations (LA-DRMs) that conventional Sanger sequencing cannot reliably detect. To fully understand the significance of LA-DRMs, it is necessary to integrate NGS data with clinical and demographic data. However, freely available tools for NGS-based HIV-1 drug resistance analysis do not integrate these data. This poses a challenge in interpretation of the impact of LA-DRMs, mainly for resource-limited settings due to the shortage of bioinformatics expertise. To address this challenge, we present HIVseqDB, a portable, secure, and user-friendly resource for integrating NGS data with associated clinical and demographic data for analysis of HIV drug resistance. HIVseqDB currently supports uploading of NGS data and associated sample data, HIV-1 drug resistance data analysis, browsing of uploaded data, and browsing and visualizing of analysis results. Each function of HIVseqDB corresponds to an individual Django application. This ensures efficient incorporation of additional features with minimal effort. HIVseqDB can be deployed on various computing environments, such as on-premises high-performance computing facilities and cloud-based platforms. Availability and implementation: HIVseqDB is available at https://github.com/AlfredUg/HIVseqDB. A deployed instance of HIVseqDB is available at https://hivseqdb.org.","journal":"Bioinformatics Advances","year":2024,"id":470363,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":29.844511487584125,"corpus_rank":8690,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7825,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":12.5,"fair_percentile":28.767960868236013,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":709776,"name":"Daudi Jjingo","orcid":"0000-0003-1685-9234","position":1,"is_corresponding":false},{"id":499545,"name":"Nicholas Bbosa","orcid":"0000-0003-1280-675X","position":2,"is_corresponding":false},{"id":621552,"name":"Daniel Lule Bugembe","orcid":"0000-0002-5616-515X","position":3,"is_corresponding":false},{"id":342585,"name":"David Patrick Kateete","orcid":"0000-0001-8075-3069","position":4,"is_corresponding":false},{"id":517393,"name":"I. King Jordan","orcid":"0000-0003-4996-2203","position":5,"is_corresponding":false},{"id":36860,"name":"Pontiano Kaleebu","orcid":"0000-0001-9706-2977","position":6,"is_corresponding":false},{"id":36881,"name":"Deogratius Ssemwanga","orcid":"0000-0001-9675-4234","position":7,"is_corresponding":false},{"id":342584,"name":"Alfred Ssekagiri","orcid":"0000-0002-6549-3550","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-19T02:05:36.656771Z","pmid":"38312948","pmcid":"PMC10834361","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":0.0,"fair_a":0.0,"fair_i":20.0,"fair_r":25.0,"fair_zscore":-0.8688,"fair_rationale":{"fair_score":12.5,"has_llm":true,"taxonomy_version":"fair_taxonomy_v5","dimensions":{"F":{"name":"Findable","score":0.0,"criteria":[{"key":"f_dataset_pid","label":"Persistent identifier for the data","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":null,"grounded":false,"rationale":"The paper does not present its own dataset; it describes a software tool and uses a public dataset for demonstration. 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Prefer open genomics / sequencing formats such as FASTQ, BAM or VCF.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"The paper does not present its own dataset; it describes a software tool and uses a public dataset for demonstration.","gain":8.33,"priority":"important","scored":true},{"key":"r_versioning","dimension":"R","label":"Snapshot identified","action":"Version the deposit and cite the exact version analysed (a version-specific DOI, or an accession with its version suffix). 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