{"doi":"10.1093/bioadv/vbac051","title":"Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis","abstract":"Motivation: Unsupervised clustering of single-cell transcriptomics is a powerful method for identifying cell populations. Static visualization techniques for single-cell clustering only display results for a single resolution parameter. Analysts will often evaluate more than one resolution parameter but then only report one. Results: We developed Cell Layers, an interactive Sankey tool for the quantitative investigation of gene expression, co-expression, biological processes and cluster integrity across clustering resolutions. Cell Layers enhances the interpretability of single-cell clustering by linking molecular data and cluster evaluation metrics, providing novel insight into cell populations. Availability and implementation: https://github.com/apblair/CellLayers.","journal":"Bioinformatics Advances","year":2022,"id":287558,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":967602,"name":"Robert Hu","orcid":"0000-0003-0402-1039","position":1,"is_corresponding":false},{"id":628575,"name":"Elie N. Farah","orcid":"0000-0002-2412-0950","position":2,"is_corresponding":false},{"id":968012,"name":"Neil C Chi","orcid":null,"position":3,"is_corresponding":false},{"id":21361,"name":"Katherine S. Pollard","orcid":"0000-0002-9870-6196","position":4,"is_corresponding":false},{"id":21352,"name":"Pawel F. Przytycki","orcid":"0000-0002-3360-6936","position":5,"is_corresponding":false},{"id":266942,"name":"Irfan S. Kathiriya","orcid":"0000-0003-1207-1490","position":6,"is_corresponding":false},{"id":44510,"name":"Benoit G. Bruneau","orcid":"0000-0002-0804-7597","position":7,"is_corresponding":false},{"id":24439,"name":"Andrew P. Blair","orcid":"0000-0002-3196-6233","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T00:30:01.051685Z","pmid":"35967929","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}