{"doi":"10.1093/bib/bbaf700","title":"Emerging insights into enhancer RNAs: biogenesis, function, mechanism, and disease implication","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>In current years, the molecular mechanisms through which enhancer-derived noncoding RNAs—enhancer RNAs (eRNAs) have been increasingly elucidated. eRNAs are not mere as transcript products but considered as a marker of active enhancers, usually characterized by bidirectional transcription, lack of poly(A) tails and rapid degradation. Multiple lines of evidence have demonstrated eRNAs are involved in a number of regulation processes such as enhancer-promoter (E-P) looping, recruitment of transcriptional co-activators, regulation of RNA polymerase II (Pol II) pause release, and induction of R-loops, thereby enabling precise control of gene expression. Besides, the tissue-specific regulatory mechanisms of eRNAs in diverse diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders are being progressively elucidated, offering potential novel targets for precision diagnosis and therapy. This review systematically synthesizes recent advances in eRNA research, elucidating structural features, transcription processes, functions, regulatory mechanisms, detection, data resources, disease associations and proposing promising prospects for eRNA-targeted precision therapeutics.</jats:p>","journal":"Briefings in Bioinformatics","year":2026,"id":631445,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1636408,"name":"Xiuchong Yu","orcid":null,"position":1,"is_corresponding":false},{"id":1636409,"name":"Heting Liu","orcid":null,"position":2,"is_corresponding":false},{"id":1636411,"name":"Yuezhu Tao","orcid":null,"position":3,"is_corresponding":false},{"id":1636413,"name":"Chunhui Huang","orcid":null,"position":4,"is_corresponding":false},{"id":1256682,"name":"Yang Xi","orcid":"0000-0002-0648-1728","position":5,"is_corresponding":false},{"id":978128,"name":"Qi Liao","orcid":"0000-0002-1532-4484","position":6,"is_corresponding":false},{"id":1636407,"name":"Meiqian Qiu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Emerging insights into enhancer RNAs: biogenesis, function, mechanism, and disease implication","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>In current years, the molecular mechanisms through which enhancer-derived noncoding RNAs—enhancer RNAs (eRNAs) have been increasingly elucidated. eRNAs are not mere as transcript products but considered as a marker of active enhancers, usually characterized by bidirectional transcription, lack of poly(A) tails and rapid degradation. Multiple lines of evidence have demonstrated eRNAs are involved in a number of regulation processes such as enhancer-promoter (E-P) looping, recruitment of transcriptional co-activators, regulation of RNA polymerase II (Pol II) pause release, and induction of R-loops, thereby enabling precise control of gene expression. Besides, the tissue-specific regulatory mechanisms of eRNAs in diverse diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders are being progressively elucidated, offering potential novel targets for precision diagnosis and therapy. This review systematically synthesizes recent advances in eRNA research, elucidating structural features, transcription processes, functions, regulatory mechanisms, detection, data resources, disease associations and proposing promising prospects for eRNA-targeted precision therapeutics.</jats:p>","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41652928","pmcid":"PMC12881689","openalex_id":"https://openalex.org/W7128195548","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China General Program","grant_id":"No. 32470722","title":null},{"funder_name":"The Zhejiang Province Vanguard Goose-Leading Initiative","grant_id":"No. 2025C01114","title":null},{"funder_name":"Ningbo Key Research and Development Program","grant_id":"No. 2023Z226","title":null},{"funder_name":"Ningbo Key Research and Development Program","grant_id":"No. 2023Z171","title":null},{"funder_name":"Ningbo Natural Science Foundation","grant_id":"No. 2021 J124","title":null},{"funder_name":"Ningbo Natural Science Foundation","grant_id":"No. 2023 J167, 2024QL033","title":null},{"funder_name":"Medical and Health Science and Technology Project of Zhejiang Province","grant_id":"2025KY1368","title":null},{"funder_name":"Medical and Health Science and Technology Project of Zhejiang Province","grant_id":"2024KY1500","title":null},{"funder_name":"Medical and Health Science and Technology Project of Zhejiang Province","grant_id":"2024KY1535","title":null},{"funder_name":"K.C. Wong Magna Fund of Ningbo University","grant_id":"","title":null},{"funder_name":"K.C. Wong Magna Fund of Ningbo University","grant_id":"","title":null}],"total_grants":11,"fwci":1.6087,"citation_percentile":0.84603264,"influential_citations":0,"citation_trend":[{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1093/bib/bbaf700","host_type":"journal"},{"url":"https://doi.org/10.1093/bib/bbaf700","host_type":"publisher"},{"url":"https://academic.oup.com/bib/article-pdf/27/1/bbaf700/66801166/bbaf700.pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41652928","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12881689","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12881689/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12881689","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12881689?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Genomics and Chromatin Dynamics","Nuclear Receptors and Signaling","Chromatin Remodeling and Cancer","Humans","Enhancer RNAs","Neoplasms","Neurodegenerative Diseases","Animals","Enhancer Elements, Genetic","Transcription, Genetic","RNA Polymerase II","Gene Expression Regulation","Cardiovascular Diseases","RNA, Untranslated","Promoter Regions, Genetic"],"mesh_terms":["Enhancer RNAs","Animals","Cardiovascular Diseases","Enhancer Elements, Genetic","Gene Expression Regulation","Humans","Neoplasms","Promoter Regions, Genetic","RNA Polymerase II","Transcription, Genetic","Neurodegenerative Diseases","RNA, Untranslated"],"keywords":["Enhancer","Enhancer RNAs","Disease","Transcription (linguistics)","Regulation of gene expression","Gene","Transcriptional regulation","Resources","Function","Biogenesis","Mechanism","Detection","Ernas","Disease Implication"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T23:38:31.876997Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}