{"doi":"10.1093/bib/bbae131","title":"Leveraging multi-omics data to empower quantitative systems pharmacology in immuno-oncology","abstract":"Understanding the intricate interactions of cancer cells with the tumor microenvironment (TME) is a pre-requisite for the optimization of immunotherapy. Mechanistic models such as quantitative systems pharmacology (QSP) provide insights into the TME dynamics and predict the efficacy of immunotherapy in virtual patient populations/digital twins but require vast amounts of multimodal data for parameterization. Large-scale datasets characterizing the TME are available due to recent advances in bioinformatics for multi-omics data. Here, we discuss the perspectives of leveraging omics-derived bioinformatics estimates to inform QSP models and circumvent the challenges of model calibration and validation in immuno-oncology.","journal":"Briefings in Bioinformatics","year":2024,"id":432104,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8617,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":323175,"name":"Hanwen Wang","orcid":"0000-0001-5480-431X","position":1,"is_corresponding":false},{"id":1092078,"name":"Alberto Ippolito","orcid":null,"position":2,"is_corresponding":false},{"id":696530,"name":"Shuming Zhang","orcid":"0000-0002-2231-9317","position":3,"is_corresponding":false},{"id":11499,"name":"Elana J. Fertig","orcid":"0000-0003-3204-342X","position":4,"is_corresponding":false},{"id":299224,"name":"Aleksander S. Popel","orcid":"0000-0002-6706-9235","position":5,"is_corresponding":false},{"id":1035009,"name":"Theinmozhi Arulraj","orcid":"0000-0002-7258-7512","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T01:59:35.267142Z","pmid":"38557676","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}