{"doi":"10.1093/alcalc/agad052","title":"Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients","abstract":"BACKGROUND: Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed. AIMS: In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease. METHODS: In this retrospective cohort study, we used the Mass General Brigham Biobank to investigate the impact of both moderate-high and light-intensity exercise on the development of ALD in patients with AUD, using clinician-provided diagnostic International Classification of Diseases 10 codes. Exercise was evaluated using a questionnaire completed after an AUD diagnosis, and before evidence of liver disease. Cox regressions were used to generate hazard ratios (HRs) for the development of ALD. RESULTS: 1987 patients met inclusion criteria. These patients were followed for an average of 10.7 years. In multivariable analyses, we found that patients that reported at least 2.5 h of moderate-high intensity exercise/week (confidence interval recommendation for exercise) were less likely to develop ALD compared to patients that did not exercise (HR: 0.26, 95%CI: 0.085-0.64, P = 0.007). Indeed, each hour of moderate-high intensity exercise was associated with progressively decreasing odds of developing ALD (HR: 0.76, 95%CI: 0.58-0.91, P = 0.02). Conversely, patients who did not engage in any moderate-high intensity exercise were more likely to develop ALD (HR: 2.76, 95%CI: 1.44-5.40, P = 0.003). CONCLUSIONS: In our cohort, patients with AUD who reported moderate-high intensity exercise showed a lower association with incidence of ALD development than patients who did not exercise.","journal":"Alcohol and Alcoholism","year":2023,"id":367278,"datarank":0.3190308345964717,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.050266914212263404,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.050266914212263404,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":5,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9639,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":733863,"name":"Augustin Vannier","orcid":"0000-0002-9467-0480","position":1,"is_corresponding":false},{"id":94138,"name":"Stephanie Tsai","orcid":"0000-0001-7549-3418","position":2,"is_corresponding":false},{"id":1124885,"name":"Rachel Mahle","orcid":null,"position":3,"is_corresponding":false},{"id":1021379,"name":"Paige McLean Diaz","orcid":"0000-0002-1289-9709","position":4,"is_corresponding":false},{"id":707558,"name":"Eric M. Przybyszewski","orcid":"0000-0001-5664-3361","position":5,"is_corresponding":false},{"id":1124431,"name":"Prasanna K. Challa","orcid":"0009-0007-4043-3387","position":6,"is_corresponding":false},{"id":734416,"name":"Suraj J. Patel","orcid":null,"position":7,"is_corresponding":false},{"id":264141,"name":"Joji Suzuki","orcid":"0000-0001-5659-6147","position":8,"is_corresponding":false},{"id":678266,"name":"Esperance Schaefer","orcid":"0000-0002-7198-3863","position":9,"is_corresponding":false},{"id":105007,"name":"Russell P. Goodman","orcid":"0000-0003-3881-7895","position":10,"is_corresponding":false},{"id":315633,"name":"Jay Luther","orcid":"0000-0001-9964-7696","position":11,"is_corresponding":false},{"id":846396,"name":"Jessica E.S. Shay","orcid":"0000-0001-7799-1349","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:15:12.215513Z","pmid":"37565935","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}