{"doi":"10.1093/alcalc/agab033","title":"Alcohol Consumption and Tryptophan Metabolism Among People with HIV Prior to Antiretroviral Therapy Initiation: The Uganda ARCH Cohort Study","abstract":"AIMS: Alcohol is hypothesized to have effects on the kynurenine pathway of tryptophan catabolism, a potential mechanism for alcohol-induced depression and aggression. A biomarker of this pathway, the plasma kynurenine to tryptophan ratio (K/T ratio), has been associated with HIV progression, mortality and depression. Our aim was to assess whether hazardous alcohol consumption is associated higher K/T ratio among people with HIV. METHODS: Participants were a subset of the Uganda Alcohol Research Collaboration on HIV/AIDS Cohort. Alcohol consumption was categorized (abstinent, moderate and hazardous alcohol use) using the Alcohol Use Disorders Identification Test-Consumption and phosphatidylethanol (PEth). K/T ratio was the primary outcome. We used linear regression adjusted for age, sex, FIB-4, hepatitis B surface antigen, log (HIV viral load) to estimate the association between alcohol consumption and K/T ratio. RESULTS: Compared to abstinent participants, hazardous drinkers and moderate drinkers had higher K/T ratio but these differences did not reach statistical significance. CONCLUSIONS: Our results suggest that hazardous alcohol consumption, in the context of untreated HIV infection, may not significantly alter kynurenine to tryptophan ratio as a measure of activity of the kynurenine pathway of tryptophan metabolism.","journal":"Alcohol and Alcoholism","year":2021,"id":211901,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":503281,"name":"Leah S. Forman","orcid":"0000-0003-1953-2739","position":1,"is_corresponding":false},{"id":518275,"name":"Michael Winter","orcid":null,"position":2,"is_corresponding":false},{"id":446874,"name":"Debbie M. Cheng","orcid":"0000-0002-2206-3059","position":3,"is_corresponding":false},{"id":454686,"name":"Christine Ngabirano","orcid":"0000-0003-0348-316X","position":4,"is_corresponding":false},{"id":416057,"name":"Nneka Emenyonu","orcid":"0000-0003-4376-7810","position":5,"is_corresponding":false},{"id":239685,"name":"Peter W. Hunt","orcid":"0000-0002-4571-4870","position":6,"is_corresponding":false},{"id":724104,"name":"Yong Huang","orcid":"0000-0002-0809-1897","position":7,"is_corresponding":false},{"id":416058,"name":"Winnie Muyindike","orcid":"0000-0002-6694-2645","position":8,"is_corresponding":false},{"id":315654,"name":"Jeffrey H. Samet","orcid":"0000-0002-0897-3400","position":9,"is_corresponding":false},{"id":416059,"name":"Judith A. Hahn","orcid":"0000-0002-2697-8264","position":10,"is_corresponding":false},{"id":463614,"name":"Kaku So‐Armah","orcid":"0000-0003-1505-6384","position":11,"is_corresponding":false},{"id":802307,"name":"Pierre Frantz","orcid":null,"position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T23:52:23.670339Z","pmid":"34027552","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}