{"doi":"10.1093/ajh/hpac085","title":"Blood Pressure and Body Composition During First Year of Antiretroviral Therapy in People With HIV Compared With HIV-Uninfected Community Controls","abstract":"BACKGROUND: Body composition changes may explain the rapid increase in blood pressure (BP) in people with HIV (PWH) during the first year of antiretroviral therapy. METHODS: We analyzed data from a cohort of PWH and HIV-uninfected adults from the same communities in Mwanza, Tanzania. Blood pressure (BP, mm Hg) and body composition data were collected at baseline and 12-month follow-up. We used multivariable linear regression to compare BP changes in PWH and HIV-uninfected adults, and the relationship between changes in body composition and changes in BP. RESULTS: BP data were available for 640 PWH and 299 HIV-uninfected adults. Sixty-four percent were women and the mean age was 38 years. In PWH, systolic BP (SBP) increased (114-118) whereas SBP decreased (125-123) in HIV-uninfected participants. Fat mass increased by 1.6 kg on average in PWH and was strongly associated with the change in BP (P < 0.001). The greater increase in SBP in PWH was partly explained by the lower baseline SBP but PWH still experienced a 2.2 (95% CI: 0.3-4.2) greater increase in SBP after adjustment. Weight gain partially mediated the relationship between HIV and SBP increase in PWH; a 1-kg increase in fat mass accounted for 0.8 (95% CI: 0.6-1.1) increase in SBP. CONCLUSIONS: Weight and fat mass increase rapidly in PWH during the first 12 months of antiretroviral therapy and contribute to a rapid increase in SBP. Interventions to prevent excessive increase in fat mass are needed for PWH.","journal":"American Journal of Hypertension","year":2022,"id":269713,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":318239,"name":"Mette Frahm Olsen","orcid":"0000-0002-5742-6403","position":1,"is_corresponding":false},{"id":318234,"name":"Suzanne Filteau","orcid":"0000-0002-1119-6825","position":2,"is_corresponding":false},{"id":318236,"name":"Brenda Kitilya","orcid":"0000-0003-0734-5944","position":3,"is_corresponding":false},{"id":318233,"name":"Kidola Jeremiah","orcid":"0000-0001-7900-9689","position":4,"is_corresponding":false},{"id":318238,"name":"Rikke Krogh‐Madsen","orcid":"0000-0003-4914-2715","position":5,"is_corresponding":false},{"id":640603,"name":"Jim Todd","orcid":"0000-0001-5918-4914","position":6,"is_corresponding":false},{"id":318244,"name":"Henrik Friis","orcid":"0000-0002-2848-2940","position":7,"is_corresponding":false},{"id":318235,"name":"Daniel Faurholt‐Jepsen","orcid":"0000-0001-8561-0155","position":8,"is_corresponding":false},{"id":318245,"name":"George PrayGod","orcid":"0000-0002-0329-4839","position":9,"is_corresponding":false},{"id":332197,"name":"Robert N. Peck","orcid":"0000-0002-4526-2480","position":10,"is_corresponding":false},{"id":318237,"name":"Bazil Baltazar Kavishe","orcid":"0000-0003-4839-4590","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T00:27:22.602796Z","pmid":"35881168","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}