{"doi":"10.1093/ajh/hpac056","title":"Low Diastolic Blood Pressure and Mortality in Older Women. Results From the Women’s Health Initiative Long Life Study","abstract":"BACKGROUND: Recommended systolic blood pressure targets often do not consider the relationship of low diastolic blood pressure (DBP) levels with cardiovascular disease (CVD) and all-cause mortality risk, which is especially relevant for older people with concurrent comorbidities. We examined the relationship of DBP levels to CVD and all-cause mortality in older women in the Women's Health Initiative Long Life Study (WHI-LLS). METHODS: The study sample included 7,875 women (mean age: 79 years) who underwent a blood pressure measurement at an in-person home visit conducted in 2012-2013. CVD and all-cause mortality were centrally adjudicated. Hazard ratios (HRs) were obtained from adjusted Cox proportional hazards models. RESULTS: After 5 years follow-up, all-cause mortality occurred in 18.4% of women. Compared with a DBP of 80 mm Hg, the fully adjusted HR for mortality was 1.33 (95% confidence interval [CI]: 1.04-1.71) for a DBP of 50 mm Hg and 1.67 (95% CI: 1.29-2.16) for a DBP of 100 mm Hg. The HRs for CVD were 1.14 (95% CI: 0.78-1.67) for a DBP of 50 mm Hg and HR 1.50 (95% CI: 1.03-2.17) for a DBP of 100 mm Hg. The nadir DBP associated with lowest mortality risk was 72 mm Hg overall. CONCLUSIONS: In older women, consideration should be given to the potential adverse effects of low and high DBP. Low DBP may serve as a risk marker. DBP target levels between 68 and 75 mm Hg may avoid higher mortality risk.","journal":"American Journal of Hypertension","year":2022,"id":276562,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":540490,"name":"Aileen P. McGinn","orcid":null,"position":1,"is_corresponding":false},{"id":493322,"name":"Victor Kamensky","orcid":null,"position":2,"is_corresponding":false},{"id":264287,"name":"Matthew Allison","orcid":"0000-0003-0777-8272","position":3,"is_corresponding":false},{"id":75616,"name":"Marcia L. Stefanick","orcid":"0000-0002-0284-6996","position":4,"is_corresponding":false},{"id":600860,"name":"Peter F. Schnatz","orcid":"0000-0002-5769-4889","position":5,"is_corresponding":false},{"id":299191,"name":"Lewis H. Kuller","orcid":"0000-0002-7148-8416","position":6,"is_corresponding":false},{"id":225663,"name":"Jeffrey S. Berger","orcid":"0000-0001-8216-4647","position":7,"is_corresponding":false},{"id":68180,"name":"Karen Johnson","orcid":null,"position":8,"is_corresponding":false},{"id":11827,"name":"Nazmus Saquib","orcid":"0000-0002-2819-2839","position":9,"is_corresponding":false},{"id":383464,"name":"Lorena García","orcid":"0000-0002-9976-761X","position":10,"is_corresponding":false},{"id":364878,"name":"Phyllis A. Richey","orcid":"0000-0002-0757-212X","position":11,"is_corresponding":false},{"id":11268,"name":"JoAnn E. Manson","orcid":"0000-0002-9426-7595","position":12,"is_corresponding":false},{"id":947589,"name":"Michael H. Alderman","orcid":null,"position":13,"is_corresponding":false},{"id":303808,"name":"Sylvia Wassertheil‐Smoller","orcid":"0000-0002-5447-4653","position":14,"is_corresponding":false},{"id":380764,"name":"Bernhard Haring","orcid":"0000-0001-6109-431X","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:28:30.709588Z","pmid":"35522983","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}