{"doi":"10.1093/ajh/hpab186","title":"From the Editor-in-Chief: Issue at a Glance","abstract":null,"journal":"American Journal of Hypertension","year":2022,"id":642175,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":305577,"name":"Ernesto L. Schiffrin","orcid":"0000-0002-4502-2823","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"From the Editor-in-Chief: Issue at a Glance","abstract":"The current issue of the American Journal of Hypertension for February 2022 begins with Commentaries by Cuspidi et al.1 and by K.M. Wang and T.I. Chang2 on original papers that will be addressed with the corresponding original manuscripts. Air pollution from cooking and heating with coal and biomass stoves may contribute to the development of hypertension and vascular damage. Using mixed-effects regression models, Kanagasabai et al.3 investigated the associations of household air pollution with BP and the vasculature in 753 adults from 3 provinces in China. They found that household air pollution is associated with higher BP and with greater carotid intima media thickness and total plaque area but they could not demonstrate increases in stiffness of the aorta. The next original article by Akinyelure et al.,4 addresses the question of whether not having a healthcare visit in the past year is associated with a higher likelihood of uncontrolled BP among subjects with hypertension. Using data from the US National Health and Nutrition Examination Survey (NHANES) 2013-2018 (n = 5,985), the authors examined factors associated with not having a healthcare visit in the past year among US adults with hypertension. 7.0% of US adults with hypertension reported not having a healthcare visit in the past year. Those without versus with a healthcare visit in the past year were less likely to be aware that they had hypertension, to be taking antihypertensive medication, and to have controlled BP (<140/90 mmHg). After multivariable adjustment, not having a healthcare visit in the past year was more common among US adults without health insurance, and among those subjects who smoked cigarettes and who had heavy versus no alcohol consumption. Also, not having a healthcare visit in the past year was more common among individuals without diabetes or a history of atherosclerotic cardiovascular disease, and those not taking a statin. The authors concluded that interventions should be considered to ensure all adults with hypertension have annual healthcare visits. It is possible that subjects who are smokers and heavy alcohol consumers will not be psychologically inclined to try to see a healthcare practitioner, especially if they are not diabetic or have CVD. Wang et al.5 carried out a study on 242 hypertensive patients with obstructive sleep apnea (OSA, 52 mild, 71 moderate and 119 severe) in order to establish associations between aortic root diameter and measures of severity in OSA patients. The authors report that severe OSA associates with a greater aortic root diameter. In an accompanying Commentary, Cuspidi et al.1 examined the mechanisms underlying unfavorable cardiovascular remodeling in OSA. These include intermittent hypoxia, sleep fragmentation, intrathoracic pressure changes, sympathetic activation, transient blood pressure elevation, increased transmural pressure, inflammation, oxidative stress, release of vasoactive agents, tachycardia and presence of comorbidities. The authors conclude that further larger studies based on multiple aortic diameter measurements are needed in the future to better delineate the relationship between OSA and vascular damage. In the next paper in this issue, Paré et al.6 used reservoir-wave analysis to separate the arterial waveform into reservoir and excess pressure (XSP) components (the latter analogous to flow and related to left ventricular workload). The authors examined whether XSP increases after creation of an arteriovenous fistula (AVF) in end-stage renal disease using arterial tonometry and carotid-femoral pulse wave velocity in thirty-eight patients. In this study, creation of an AVF resulted in increased XSP in this population, despite improvement in diastolic BP and aortic stiffness, which underlines the impact of AVF on the cardiovascular system. The following article is by Liu et al.,7 who investigated whether hydrogen-rich saline (HRS) can attenuate myocardial fibrosis in spontaneously hypertensive rats (SHRs) and the mechanisms involved. The authors found that HRS reduced oxidative stress and improved myocardial collagen content, potentially related to inhibition of TGF-β signaling. They concluded that their results suggested that HRS could be an effective therapeutic strategy for myocardial fibrosis. Strict postoperative arterial BP control is needed for patients undergoing carotid endarterectomy (CEA) because most adverse events are a consequence of hemodynamics. Fassaert et al.8 assessed whether BP monitoring with noninvasive beat-to-beat ClearSight finger BP (BPCS) could replace invasive beat-to-beat radial artery BP (BPRAD) in the postoperative phase. This single-center clinical validation study evaluated 48 patients and demonstrated that noninvasive MAP, but not systolic or diastolic BP, was similar to invasive BPRAD during postoperative observation following CEA. However, systolic BP is currently followed in postoperative monitoring to adjust BP therapy. Accordingly, BPCS is not a reliable alternative for BPRAD. The consequences on the kidney of long-term blood pressure variability (BPV) in healthy older adults are unknown. Ernst et al.9 investigated this association in the ASPirin in Reducing Events in the Elderly (ASPREE) trial participants. Australian and US individuals aged ≥70 years were recruited and followed with annual visits for a median of 4.7 years. Incident CKD occurred in 1,829 of 6,759 participants (27.2%), and more commonly in subjects with the highest BPV. These subjects had the lowest eGFR and highest log albumin/creatinine ratio (ACR). However, the trajectories of eGFR and log ACR did not differ across BPV tertiles. Although CKD and markers of reduced kidney function occurred more commonly in subjects with higher BPV, BPV did not influence the decline in kidney function over time in older adults in good health. In a related Commentary, K.M. Wang and T.I. Chang2 indicate that the study was well conducted but that the relatively infrequent BP measurements available represent an important limitation of the trial. They point out that there are no set standards for how many BP measurements are optimal, which adds to the difficulties of studying BPV. Despite the absence of association between BPV and kidney function in this study, the authors of the Commentary believe that BPV is a parameter worthy of further investigation, considering prior evidence that higher BPV is associated with stroke. However, in the meantime, BP management should continue to depend on systolic BP. In order to assess whether in the SPRINT trial, adherence and cardiovascular outcomes were associated independently of intervention, Glasser et al.10 administered the 8-item Morisky Medication Adherence Scale (MMAS-8) at baseline, and at the 12- and 48-month visit. After adjusting for covariates, there was no association between the baseline MMAS-8 and the likelihood of the primary composite endpoint, any of the secondary endpoints, or BP control. There was also no difference in the MMAS-8 over time by treatment arm assignment. This indicated that in SPRINT, medication adherence as measured by MMAS-8 was not associated with outcomes or BP control. Based on observations that Vitamin D3 supplementation could be a potential intervention to prevent orthostatic hypotension (OH), Juraschek et al.11 used data from the Study to Understand Fall Reduction and Vitamin D in You (STURDY), to determine if higher doses of vitamin D3 reduced the risk of OH in adults 70 years and older with low serum 25-hydroxyvitamin D. Among 688 participants over the maximum 2-year follow-up period, compared with 200 IU/day, 1,000+ IU/day was not associated with seated, standing, or orthostatic BP, and it did not lower risk of OH or orthostatic symptoms. In the final article in this issue of the Journal, Maack et al.12 evaluated measurement of waist circumference for prediction of preeclampsia in order to identify women at high risk for preeclampsia to decide whether to start treatment with prophylactic aspirin. They compared the prediction models with current ones that incorporate BMI. The authors studied a population-based cohort of 4,696 women. They found that a large waist circumference was associated with a higher risk of preeclampsia, but that adding waist circumference to a prediction model for preeclampsia that already includes BMI did not improve the model’s performance.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35106533","pmcid":null,"openalex_id":"https://openalex.org/W4205881805","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://academic.oup.com/ajh/article-pdf/35/2/113/42361725/hpab186.pdf","host_type":"journal"},{"url":"https://academic.oup.com/ajh/article-pdf/35/2/113/42361725/hpab186.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/ajh/article-pdf/35/2/113/46382257/hpab186.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/ajh/hpab186","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35106533","host_type":"repository"}],"fields_of_study":["Cardiovascular Health and Disease Prevention","Humans","Hypertension"],"mesh_terms":["Humans","Hypertension"],"keywords":["Medicine","Editor in chief","Management"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T21:47:58.569946Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}