{"doi":"10.1093/aje/kwn259","title":"Estimating Influenza Vaccine Efficacy From Challenge and Community-based Study Data","abstract":null,"journal":"American Journal of Epidemiology","year":2008,"id":599117,"datarank":0.6749714505495399,"base_score":4.499809670330265,"endowment":4.499809670330265,"self_citation_contribution":0.6749714505495399,"citation_network_contribution":0.0,"self_endowment_contribution":0.6749714505495399,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":89,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1535497,"name":"M. E. Halloran","orcid":null,"position":1,"is_corresponding":false},{"id":1198117,"name":"L. Matrajt","orcid":null,"position":2,"is_corresponding":false},{"id":1535498,"name":"I. M. Longini","orcid":null,"position":3,"is_corresponding":false},{"id":1535496,"name":"N. E. Basta","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Estimating Influenza Vaccine Efficacy From Challenge and Community-based Study Data","abstract":"In this paper, the authors provide estimates of 4 measures of vaccine efficacy for live, attenuated and inactivated influenza vaccine based on secondary analysis of 5 experimental influenza challenge studies in seronegative adults and community-based vaccine trials. The 4 vaccine efficacy measures are for susceptibility (VE(S)), symptomatic illness given infection (VE(P)), infection and illness (VE(SP)), and infectiousness (VE(I)). The authors also propose a combined (VE(C)) measure of the reduction in transmission in the entire population based on all of the above efficacy measures. Live influenza vaccine and inactivated vaccine provided similar protection against laboratory-confirmed infection (for live vaccine: VE(S) = 41%, 95% confidence interval (CI): 15, 66; for inactivated vaccine: VE(S) = 43%, 95% CI: 8, 79). Live vaccine had a higher efficacy for illness given infection (VE(P) = 67%, 95% CI: 24, 100) than inactivated vaccine (VE(P) = 29%, 95% CI: -19, 76), although the difference was not statistically significant. VE(SP) for the live vaccine was higher than for the inactivated vaccine. VE(I) estimates were particularly low for these influenza vaccines. VE(SP) and VE(C) can remain high for both vaccines, even when VE(I) is relatively low, as long as the other 2 measures of vaccine efficacy are relatively high.","is_dataset_classified":null,"base_score":4.499809670330265,"endowment":4.499809670330265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18974084","pmcid":"PMC2638553","openalex_id":"https://openalex.org/W2168552128","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"U01 GM070749","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"U01-GM070749","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI032042","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01-AI32042","title":null},{"funder_name":"National Institutes of Health","grant_id":"5U01GM070749-04","title":"Containing Bioterroist and Emerging Infectious Diseases"},{"funder_name":"National Institutes of Health","grant_id":"2R01AI032042-12A2","title":"Methods for Evaluating Vaccine Efficacy"}],"total_grants":6,"fwci":6.371,"citation_percentile":0.97023885,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":8},{"year":2014,"count":4},{"year":2015,"count":5},{"year":2016,"count":2},{"year":2017,"count":6},{"year":2018,"count":4},{"year":2020,"count":3},{"year":2021,"count":6},{"year":2022,"count":4},{"year":2024,"count":5},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"bronze","license":"implied-oa","oa_locations":[{"url":"https://academic.oup.com/aje/article-pdf/168/12/1343/363643/kwn259.pdf","host_type":"journal"},{"url":"https://academic.oup.com/aje/article-pdf/168/12/1343/363643/kwn259.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/aje/article-pdf/168/12/1343/363643/kwn259.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/aje/kwn259","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18974084","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2638553","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2638553","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2638553?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1093/aje/kwn259","host_type":""},{"url":"https://dx.doi.org/10.1093/aje/kwn259","host_type":""}],"fields_of_study":["Influenza Virus Research Studies","COVID-19 epidemiological studies","Pneumonia and Respiratory Infections","03 medical and health sciences","0302 clinical medicine","Disease Outbreaks","Humans","Influenza Vaccines","Influenza, Human","Models, Theoretical","Reproducibility of Results"],"mesh_terms":["Disease Outbreaks","Humans","Influenza, Human","Influenza Vaccines","Models, Theoretical","Reproducibility of Results"],"keywords":["Medicine","Influenza vaccine","Inactivated vaccine","Vaccine efficacy","Live attenuated influenza vaccine","Vaccination","Confidence interval","Virology","Immunology","Attenuated vaccine","Transmission (telecommunications)","Population","Internal medicine","Environmental health","Biology","Influenza Vaccines","Influenza, Human","Commentary","Humans","Reproducibility of Results","Models, Theoretical","Disease Outbreaks"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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