{"doi":"10.1093/aje/kwac011","title":"A Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility","abstract":"Some reproductive-aged individuals remain unvaccinated against coronavirus disease 2019 (COVID-19) because of concerns about potential adverse effects on fertility. Using data from an internet-based preconception cohort study, we examined the associations of COVID-19 vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with fertility among couples trying to conceive spontaneously. We enrolled 2,126 self-identified female participants aged 21-45 year residing in the United States or Canada during December 2020-September 2021 and followed them through November 2021. Participants completed questionnaires every 8 weeks on sociodemographics, lifestyle, medical factors, and partner information. We fit proportional probabilities regression models to estimate associations between self-reported COVID-19 vaccination and SARS-CoV-2 infection in both partners with fecundability (i.e., the per-cycle probability of conception), adjusting for potential confounders. COVID-19 vaccination was not appreciably associated with fecundability in either partner (female fecundability ratio (FR) = 1.08, 95% confidence interval (CI): 0.95, 1.23; male FR = 0.95, 95% CI: 0.83, 1.10). Female SARS-CoV-2 infection was not strongly associated with fecundability (FR = 1.07, 95% CI: 0.87, 1.31). Male infection was associated with a transient reduction in fecundability (for infection within 60 days, FR = 0.82, 95% CI: 0.47, 1.45; for infection after 60 days, FR = 1.16, 95% CI: 0.92, 1.47). These findings indicate that male SARS-CoV-2 infection may be associated with a short-term decline in fertility and that COVID-19 vaccination does not impair fertility in either partner.","journal":"American Journal of Epidemiology","year":2022,"id":233829,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9376,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":371913,"name":"Elizabeth E. Hatch","orcid":"0000-0001-7901-3928","position":1,"is_corresponding":false},{"id":5904,"name":"Kenneth J. Rothman","orcid":"0000-0003-2398-1705","position":2,"is_corresponding":false},{"id":372995,"name":"Tanran R. Wang","orcid":null,"position":3,"is_corresponding":false},{"id":417804,"name":"Mary D. Willis","orcid":"0000-0002-0247-7983","position":4,"is_corresponding":false},{"id":463276,"name":"Jennifer J. Yland","orcid":"0000-0001-7870-8971","position":5,"is_corresponding":false},{"id":758579,"name":"Holly M. Crowe","orcid":"0000-0001-9164-532X","position":6,"is_corresponding":false},{"id":342209,"name":"Ruth J. Geller","orcid":"0000-0001-8828-0761","position":7,"is_corresponding":false},{"id":371911,"name":"Sydney K. Willis","orcid":"0000-0002-6858-5450","position":8,"is_corresponding":false},{"id":237724,"name":"Rebecca B. Perkins","orcid":"0000-0002-7054-3014","position":9,"is_corresponding":false},{"id":361794,"name":"Annette K. Regan","orcid":"0000-0002-3879-6193","position":10,"is_corresponding":false},{"id":848918,"name":"Jessica A. Levinson","orcid":null,"position":11,"is_corresponding":false},{"id":463277,"name":"Ellen M. Mikkelsen","orcid":"0000-0003-0158-7950","position":12,"is_corresponding":false},{"id":329832,"name":"Lauren A. Wise","orcid":"0000-0003-2138-3752","position":13,"is_corresponding":false},{"id":371912,"name":"Amelia K. Wesselink","orcid":"0000-0002-3929-4451","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T00:21:31.237180Z","pmid":"35051292","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}