{"doi":"10.1093/aje/kwaa210","title":"Randomized Trial Evaluation of the Benefits and Risks of Menopausal Hormone Therapy Among Women 50–59 Years of Age","abstract":"The health benefits and risks of menopausal hormone therapy among women aged 50-59 years are examined in the Women's Health Initiative randomized, placebo-controlled trials using long-term follow-up data and a parsimonious statistical model that leverages data from older participants to increase precision. These trials enrolled 27,347 healthy postmenopausal women aged 50-79 years at 40 US clinical centers during 1993-1998, including 10,739 post-hysterectomy participants in a trial of conjugated equine estrogens and 16,608 participants with a uterus in the trial of these estrogens plus medroxyprogesterone acetate. Over a (median) 18-year follow-up period (1993-2016), risk for a global index (defined as the earliest of coronary heart disease, invasive breast cancer, stroke, pulmonary embolism, colorectal cancer, endometrial cancer, hip fracture, and all-cause mortality) was reduced with conjugated equine estrogens with a hazard ratio of 0.82 (95% confidence interval: 0.71, 0.95), and with nominally significant reductions for coronary heart disease, breast cancer, hip fracture, and all-cause mortality. Corresponding global index hazard ratio estimates of 1.06 (95% confidence interval: 0.95, 1.19) were nonsignificant for combined estrogens plus progestin, but increased breast cancer risk and reduced endometrial cancer risk were observed. These results, among women 50-59 years of age, substantially agree with the worldwide observational literature, with the exception of breast cancer for estrogens alone.","journal":"American Journal of Epidemiology","year":2020,"id":57356,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":79,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8792,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":243115,"name":"Aaron K. Aragaki","orcid":"0000-0001-5075-6437","position":1,"is_corresponding":false},{"id":243114,"name":"Rowan T. Chlebowski","orcid":"0000-0002-4212-6184","position":2,"is_corresponding":false},{"id":2543,"name":"Jacques E. Rossouw","orcid":"0000-0001-9972-0371","position":3,"is_corresponding":false},{"id":243116,"name":"Garnet L. Anderson","orcid":"0000-0001-5087-7837","position":4,"is_corresponding":false},{"id":75616,"name":"Marcia L. Stefanick","orcid":"0000-0002-0284-6996","position":5,"is_corresponding":false},{"id":243122,"name":"Jean Wactawski‐Wende","orcid":"0000-0003-3096-9595","position":6,"is_corresponding":false},{"id":299191,"name":"Lewis H. Kuller","orcid":"0000-0002-7148-8416","position":7,"is_corresponding":false},{"id":38115,"name":"Robert L. Wallace","orcid":"0000-0001-6305-4776","position":8,"is_corresponding":false},{"id":243121,"name":"Karen Johnson","orcid":"0000-0002-3493-4077","position":9,"is_corresponding":false},{"id":272433,"name":"Aladdin H. Shadyab","orcid":"0000-0002-9693-0522","position":10,"is_corresponding":false},{"id":24743,"name":"Margery Gass","orcid":null,"position":11,"is_corresponding":false},{"id":11268,"name":"JoAnn E. Manson","orcid":"0000-0002-9426-7595","position":12,"is_corresponding":false},{"id":243126,"name":"Ross L. Prentice","orcid":"0000-0003-2849-5757","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-18T21:06:31.136481Z","pmid":"33025002","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}