{"doi":"10.1093/ajcp/aqaf050","title":"Endoscopic ultrasound–guided pancreatic core-needle/microforceps biopsy is a valuable diagnostic tool for pancreatic lesions: Experience from a large academic institution","abstract":"OBJECTIVE: Endoscopic ultrasound (EUS)-guided, fine-needle core biopsy (FNB), and through-the-needle microforceps biopsy (TTNB) are latest tools for evaluating pancreatic lesions. We aim to provide subspecialty surgical pathologists' experience with EUS-FNB/TTNB in diagnosing pancreatic lesions at a large academic center. METHODS: A 3-year review identified 101 EUS pancreatic specimens submitted for surgical pathology: 87 biopsy specimens (FNB = 58, TTNB = 29) and 14 fine-needle aspirations (FNAs). Diagnoses were compared with cytology and resection specimens when available. RESULTS: Of the 101 cases, 10 had previous EUS-FNA cytology with inconclusive diagnoses. Rebiopsy with EUS-FNB/TTNB provided definitive diagnoses in 9 cases. Thirty-five cases (18 cystic and 17 solid lesions) had concurrent surgical pathology and cytology specimens. The diagnostic yield of EUS-FNB/TTNB biopsy specimens (69%) was significantly higher than that of cytology specimens (26%, P = .0017), as was the diagnostic accuracy (P = .0012). This diagnostic advantage was statistically significant in cystic lesions (FNB/TTNB [83.3%] vs cytology [16.7%] for achieving a specific diagnosis, P = .0002) but not in solid lesions (61.5% vs 46.2%, P = .6951). Only in 1 case did cytology (adenocarcinoma) provide a more definitive diagnosis than surgical pathology (high-grade dysplasia cannot exclude adenocarcinoma). CONCLUSIONS: The EUS-FNB/TTNB methods complement EUS-FNA cytology in diagnosing pancreatic lesions, and they often outperforms concurrent cytology specimens, particularly in cystic lesions.","journal":"American Journal of Clinical Pathology","year":2025,"id":538251,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9324,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":380164,"name":"Wendy L. Frankel","orcid":"0000-0003-1658-1009","position":1,"is_corresponding":false},{"id":316404,"name":"Zaibo Li","orcid":"0000-0003-1325-1696","position":2,"is_corresponding":false},{"id":320324,"name":"Dan Jones","orcid":"0000-0002-4688-3780","position":3,"is_corresponding":false},{"id":640222,"name":"Somashekar G. Krishna","orcid":"0000-0001-5748-7890","position":4,"is_corresponding":false},{"id":1022805,"name":"Ashwini Esnakula","orcid":"0000-0001-6029-0124","position":5,"is_corresponding":false},{"id":336126,"name":"Martha Yearsley","orcid":"0000-0003-0352-1277","position":6,"is_corresponding":false},{"id":1424878,"name":"Shaoli Sun","orcid":"0000-0003-0567-0196","position":7,"is_corresponding":false},{"id":1217415,"name":"Giovanni Lujan","orcid":"0000-0003-1392-6155","position":8,"is_corresponding":false},{"id":1424879,"name":"Jennifer Vazzano","orcid":"0000-0001-9977-1259","position":9,"is_corresponding":false},{"id":1425263,"name":"Wegahta Weldemichael","orcid":null,"position":10,"is_corresponding":false},{"id":527393,"name":"Peter J. Lee","orcid":"0000-0002-0510-8980","position":11,"is_corresponding":false},{"id":1269360,"name":"Hamza Shah","orcid":"0009-0008-1676-1564","position":12,"is_corresponding":false},{"id":1269852,"name":"Jordan Burlen","orcid":null,"position":13,"is_corresponding":false},{"id":1425264,"name":"George Papachristou","orcid":null,"position":14,"is_corresponding":false},{"id":1039390,"name":"Wei Chen","orcid":"0000-0002-9934-4000","position":15,"is_corresponding":false},{"id":885513,"name":"Saba Shafi","orcid":"0000-0002-8468-2402","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T02:52:21.389196Z","pmid":"40414818","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}