{"doi":"10.1093/ajcp/aqad042","title":"Progression of follicular lymphoma and related entities: Report from the 2021 SH/EAHP Workshop","abstract":"OBJECTIVES: The 2021 Society for Hematopathology and European Association for Haematopathology Workshop addressed the molecular and cytogenetic underpinnings of transformation and transdifferentiation in lymphoid neoplasms. METHODS: Session 4, \"Transformations of Follicular Lymphoma,\" and session 5, \"Transformations of Other B-Cell Lymphomas,\" included 45 cases. Gene alteration analysis and expression profiling were performed on cases with submitted formalin-fixed, paraffin embedded tissue. RESULTS: The findings from session 4 suggest that \"diffuse large B-cell lymphoma/high-grade B-cell lymphoma with rearrangements of MYC and BCL2\" is a distinct category arising from the constraints of a preexisting BCL2 translocation. TdT expression in aggressive B-cell lymphomas is associated with MYC rearrangements, immunophenotypic immaturity, and a dismal prognosis but must be differentiated from lymphoblastic -lymphoma. Cases in session 5 illustrated unusual morphologic and immunophenotypic patterns of transformation. Additionally, the findings support the role of cytogenetic abnormalities-specifically, MYC and NOTCH1 rearrangements-as well as single gene alterations, including TP53, in transformation. CONCLUSIONS: Together, these unique cases and their accompanying molecular and cytogenetic data suggest potential mechanisms for and unusual patterns of transformation in B-cell lymphomas and indicate numerous opportunities for further study.","journal":"American Journal of Clinical Pathology","year":2023,"id":359355,"datarank":0.4484566917292288,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.08877240080947313,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.08877240080947313,"corpus_percentile":58.01810164771409,"corpus_rank":5428,"citation_count":10,"citer_count":7,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6023,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":34524,"name":"Ahmet Doǧan","orcid":"0000-0001-6576-5256","position":1,"is_corresponding":false},{"id":488341,"name":"Catalina Amador","orcid":"0000-0003-0352-5526","position":2,"is_corresponding":false},{"id":700443,"name":"James R. Cook","orcid":"0000-0003-0456-8085","position":3,"is_corresponding":false},{"id":395708,"name":"Magdalena Czader","orcid":"0000-0002-6173-6500","position":4,"is_corresponding":false},{"id":593633,"name":"John R. Goodlad","orcid":"0000-0002-8385-8517","position":5,"is_corresponding":false},{"id":407370,"name":"Reza Nejati","orcid":"0000-0002-2188-156X","position":6,"is_corresponding":false},{"id":275375,"name":"Wenbin Xiao","orcid":"0000-0001-8586-8500","position":7,"is_corresponding":false},{"id":555328,"name":"Lanie E. Happ","orcid":null,"position":8,"is_corresponding":false},{"id":1110319,"name":"Clay Parker","orcid":null,"position":9,"is_corresponding":false},{"id":1110320,"name":"Elizabeth Thacker","orcid":null,"position":10,"is_corresponding":false},{"id":554649,"name":"Devang Thakkar","orcid":"0000-0002-9182-937X","position":11,"is_corresponding":false},{"id":33053,"name":"Sandeep S. Davé","orcid":"0000-0003-4848-9768","position":12,"is_corresponding":false},{"id":1110321,"name":"Mariusz Wasik","orcid":null,"position":13,"is_corresponding":false},{"id":13891,"name":"German Ott","orcid":"0000-0001-7990-6793","position":14,"is_corresponding":false},{"id":264744,"name":"Amy S. Duffield","orcid":"0000-0003-2018-1964","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T01:13:52.889556Z","pmid":"37167543","pmcid":"PMC10233403","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}